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SMILAX CHINA FRUIT EXTRACT.

Valuable CAS 90131-09-2 / ANTIMICROBIAL, ANTIOXIDANT, ASTRINGENT, HAIR CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Smilax China Fruit Extract is sourced from the berries of the Smilax china plant, a botanical historically valued for its medicinal properties. Rich in polyphenols and flavonoids, this extract offers a spectrum of potential skincare benefits, including robust antioxidant defense and targeted antimicrobial action. While studies on the specific fruit extract are emerging, comprehensive research on various parts of the Smilax china plant underscores its promising efficacy for skin health and regeneration.

Summary

antimicrobial antioxidant astringent emollient hair conditioning anti-inflammatory anti-aging wound healing skin barrier repair

Science

Mechanism of Action

Smilax China extracts exert their beneficial effects primarily through antioxidant and anti-inflammatory pathways. They effectively scavenge free radicals, mitigating oxidative stress, and possess immunomodulatory properties by inhibiting pro-inflammatory cytokines such as TNF-α, IL-6, and IL-1β, alongside suppressing NF-κB and MAPK signaling. The extract also demonstrates antimicrobial activity against Cutibacterium acnes, potentially by disrupting bacterial cell membranes. Furthermore, it can inhibit Advanced Glycation End Products (AGEs) formation and aldose reductase activity, contributing to anti-aging benefits, and promotes skin barrier repair and wound healing through enhanced keratinocyte proliferation, migration, collagen synthesis, and upregulation of key barrier proteins like filaggrin and loricrin.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Aqueous Smilax china extract demonstrated significant antioxidant potential with 63.54% DPPH free radical scavenging activity in vitro.
  2. 02 Alcoholic Smilax china extract also showed substantial antioxidant activity with 40.45% DPPH free radical scavenging activity in vitro.
  3. 03 An ethanol rhizome extract of Smilax china L. exhibited potent radical scavenging against DPPH (IC50 = 1.7 mg/mL) and ABTS+ (IC50 = 0.3 mg/mL) radicals in vitro.
  4. 04 Smilax china L. stems extract inhibited Advanced Glycation End Products (AGEs) formation in vitro.
  5. 05 Smilax china L. root extract exhibited strong antimicrobial activity against Cutibacterium acnes strains, with key compounds like quercetin (MIC 31.25 μg/mL), resveratrol (MIC 125 μg/mL), and oxyresveratrol (MIC 250 μg/mL) identified.
  6. 06 Smilax china flower absolute positively influenced skin wound healing and barrier repair by enhancing keratinocyte proliferation, migration, collagen synthesis, and the expression of filaggrin and loricrin in human epidermal keratinocytes (HaCaT cells).

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Poor solubility and limited skin permeability can present formulation challenges, suggesting the utility of advanced delivery systems such as microemulsions to optimize solubilization and enhance penetration.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

Specific safety data for 'Smilax China Fruit Extract' is limited. General 'Smilax China extract' and 'Smilax China Root Extract' dermal toxicity data is not determined.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Smilax China Fruit Extract offers valuable potential for diverse skin concerns, leveraging the robust antioxidant, anti-inflammatory, and antimicrobial properties demonstrated by the broader Smilax china plant, though more specific fruit extract studies would enhance its precision profile.

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