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Moumoujus

SMALLANTHUS SONCHIFOLIUS LEAF EXTRACT.

Insufficient Data CAS - / SKIN CONDITIONING

Smallanthus Sonchifolius Leaf Extract is derived from the yacon plant, known for its potent antioxidant and anti-inflammatory capabilities. These benefits stem from a rich profile of phenolic compounds and specific sesquiterpene lactones, offering a multi-faceted approach to skin health. It is valued for its potential in diminishing oxidative stress and mitigating inflammatory responses.

Summary

antioxidant anti-inflammatory skin conditioning

Science

Mechanism of Action

This extract exerts its benefits through a complex array of bioactive compounds, notably phenolic acids (including chlorogenic, caffeic, and ferulic acids) and flavonoids, all contributing robust antioxidant and anti-inflammatory effects. Furthermore, it contains sesquiterpene lactones like enhydrin and uvedalin, which significantly amplify these properties. These lactones specifically inhibit Nuclear Factor kappa-B (NF-kB), a pivotal regulator of immune and inflammatory pathways, thereby reducing cellular oxidative damage and inflammatory cascades.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No information suggests this ingredient is commonly used at ineffective concentrations in cosmetic formulations.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The extract's bioactive components are susceptible to degradation upon exposure to light and heat, necessitating protective measures in formulation. Encapsulation is identified as a potential strategy to preserve efficacy and ensure targeted delivery of these sensitive compounds.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Smallanthus Sonchifolius Leaf Extract lacks specific reviews by the CIR or SCCS, and its FDA cosmetic status is undefined. Oral toxicity studies in rats showed no adverse effects at high acute (e.g., 14.0 g/kg of 10% decoction) or subchronic (e.g., 0.28 g/kg/day of 10% decoction for 90 days) doses. However, *in vitro* tests indicated potential cytotoxicity and genotoxicity from crude lactone mixtures in HeLa cells, implying that highly concentrated or isolated sesquiterpene lactones within the extract warrant careful consideration regarding their specific concentration and composition in cosmetic applications.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While exhibiting promising antioxidant and anti-inflammatory mechanisms in preclinical studies, the lack of human clinical data and formal safety reviews, coupled with *in vitro* concerns for concentrated isolated components, places its comprehensive cosmetic utility as currently possessing insufficient data for a definitive recommendation.

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