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SILYBUM MARIANUM SEED EXTRACT.

Valuable CAS 84604-20-6 / SKIN CONDITIONING

Silybum Marianum Seed Extract is a potent botanical ingredient, rich in flavonolignans, offering comprehensive dermatological benefits. It effectively targets signs of aging, oxidative stress, inflammation, and various skin conditions, including acne and hyperpigmentation. This extract acts as a multifunctional powerhouse for improving overall skin health and resilience.

Antioxidant Anti-inflammatory Anti-aging Skin Conditioning UV Protectant Anti-acne Brightening Barrier Strengthening Detoxifying Hyaluronic Acid Booster Collagen Booster

Science

This extract operates via multiple pathways to enhance skin health. Its primary active compounds, particularly silymarin, function as powerful antioxidants that neutralize free radicals and mitigate oxidative stress induced by environmental factors like pollution and UV radiation, thereby combating premature skin aging. It demonstrates robust anti-inflammatory capabilities, significantly calming redness, irritation, and swelling, rendering it beneficial for sensitive or inflamed skin, and conditions such as eczema and psoriasis. Furthermore, it aids in fortifying the skin's natural barrier function. For acne-prone skin, it provides a cooling sensation, reduces sebum production, diminishes post-inflammatory hyperpigmentation, and notably interferes with the comedone-switch mechanism by modulating Keratin 75 and 79 expression and lipid droplet proteins. Specific components like silybin contribute to a brighter, more even-toned complexion by reducing dark spots and hyperpigmentation. The extract also possesses detoxifying properties and can inhibit UV-induced NF-κB activation in keratinocytes, offering protection against sunburn, inflammation, and UV damage. Critically, it stimulates the production of essential dermal components, increasing collagen III and hyaluronic acid levels within the skin.


Research

High confidence
Effective range N/A
Optimal

0.8%

Key findings

  1. 01 In clinical trials, a 0.8% concentration significantly increased collagen III levels by 23% compared to bakuchiol and 16% compared to retinol. It also boosted hyaluronic acid production by 36% relative to bakuchiol. This concentration demonstrated a significantly stronger anti-wrinkle effect than bakuchiol, reducing forehead wrinkle count by 21% and their circumference by 17%, with anti-aging outcomes comparable to retinol but without reported discomfort.
  2. 02 Long-term topical application of Silybum Marianum fruit extract over 12 months contributed to maintaining skin homeostasis in acne-prone individuals. This resulted in a significant reduction in acne lesion counts and improved seborrhea, with excellent tolerance. Its mechanism involves interfering with the comedone-switch mechanism.

Transparency

Not commonly dusted

The Formula

Solubility
Oil
Optimal pH 4.5 – 6.5
0 7 14

Safety

CIR Status
Not reviewed
Sensitization risk Low

Generally considered safe and non-irritating at standard concentrations with low reported toxicity. However, due to its botanical origin, a patch test is advised for individuals with potential plant allergies, as mild irritation may occur in some cases, particularly in combination with other problematic ingredients. Research on its safety for pregnant or breastfeeding individuals is limited, suggesting extra caution.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

Silybum Marianum Seed Extract is a valuable, multifunctional ingredient that effectively targets signs of aging and acne with impressive clinical efficacy, offering a well-tolerated alternative to traditional retinoids.


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