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SILYBUM MARIANUM CALLUS EXTRACT.

Valuable CAS 84604-20-6 / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

Silybum Marianum Callus Extract, derived from milk thistle callus, is a potent plant-based ingredient known for its extensive skin benefits. It delivers powerful antioxidant and anti-inflammatory action, significantly contributing to anti-aging, hydration, and skin tone evening.

Antioxidant Anti-inflammatory UV-protectant Skin conditioning Emollient Skin protecting Moisturizer Anti-aging Sebum regulator Brightening

Science

This ingredient actively enhances skin health through several precise mechanisms. It provides robust antioxidant protection by neutralizing free radicals, thereby shielding skin cells from environmental damage caused by pollution and UV radiation, which are key drivers of premature aging. Its anti-inflammatory properties soothe redness and irritation, diminish swelling, and specifically inhibit pro-inflammatory cytokines such as IL-6, IL-8, TNF-α, and IL-1a, rendering it highly beneficial for sensitive, inflamed, and acne-prone skin, potentially imparting a cooling sensation. Silybum Marianum Callus Extract also strengthens the skin's natural barrier, acts as a potent anti-aging agent by visibly reducing premature wrinkles and fine lines, and has been shown to increase levels of crucial structural components like collagen III and hyaluronic acid. Furthermore, it optimizes skin hydration by improving moisture content and significantly reducing transepidermal water loss (TEWL). It contributes to a brighter, more uniform complexion by decreasing melanin levels and diminishing the appearance of dark spots and hyperpigmentation. The extract also offers protection against UV radiation and photodamage, supports skin detoxification, and precisely regulates sebum production to restore skin homeostasis, particularly beneficial for acne-prone conditions. Some research indicates potential in promoting wound healing.


Research

Medium confidence
Effective range 15–125%
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

Specific optimal pH ranges for the stability of Silybum Marianum Callus Extract in cosmetic formulations are not definitively established. Existing pH information (e.g., pH 7.4) pertains to enzyme activity crucial for bioconversion processes of callus compounds into silymarin derivatives, rather than the intrinsic stability of the extract itself as a cosmetic ingredient.


Safety

CIR Status
Insufficient data
Sensitization risk Low

While a specific CIR, SCCS, or FDA safety status for Silybum Marianum Callus Extract is not available, its parent compound, Silybum Marianum Extract (milk thistle), is generally regarded as safe and non-irritating for topical application at standard concentrations. Given its plant origin, a patch test is recommended for individuals with potential plant allergies. Research on its safety during pregnancy or breastfeeding is currently limited.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

Silybum Marianum Callus Extract is a highly valuable, multi-functional ingredient, offering comprehensive benefits across all skin types, from robust antioxidant defense and anti-inflammatory action to anti-aging and sebum regulation, with a low risk of irritation.


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