Science
Mechanism of Action
This recombinant collagen type III peptide is fully homologous to the human collagen sequence, signaling the skin to activate its endogenous repair processes. It functions by significantly improving the extracellular matrix (ECM) through a dual action: stimulating the synthesis of vital ECM components, including collagen types I and III, and concurrently inhibiting enzymes like metalloproteinases (MMPs) that degrade the ECM. This comprehensive approach strengthens skin structure, improves elasticity and hydration, and enhances the dermal-epidermal junction (DEJ), leading to a reduction in wrinkles and an improvement in overall complexion.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Extensive in vitro and ex vivo studies have demonstrated that SH-POLYPEPTIDE-69 improves skin structure by stimulating collagen synthesis and inhibiting collagen breakdown, specifically by reducing collagenase activity. Efficacy was observed when the active polypeptide itself was present at concentrations between 0.05% and 0.2%.
Transparency
Dusting Analysis
There is no available data to indicate that SILKWORM SH-POLYPEPTIDE-69 is commonly 'dusted' or used at ineffective concentrations in formulations. The precise active concentration range is provided for efficacy.
The Formula
Formulation
Stability
Specific optimal pH range or detailed stability information for SH-POLYPEPTIDE-69 is not available. General observations for liquid silk and silk protein conjugates suggest potential short shelf lives and a tendency for self-assembly, which can impact physical and chemical stability. However, it is noted that these general observations may not directly apply to this specific recombinant polypeptide.
Safety
Safety Profile
SILKWORM SH-POLYPEPTIDE-69, a specific recombinant collagen type III peptide, has not been explicitly reviewed for safety by major regulatory bodies like CIR, SCCS, or FDA. While general silk proteins have been assessed, this specific synthetic peptide is distinct. Its irritancy and comedogenicity are currently listed as 'unknown' by INCIDecoder, and Paula's Choice indicates it is 'not rated'.
Your Skin
Skin Compatibility
Our Assessment
Verdict
As a precision-engineered recombinant collagen type III, SILKWORM SH-POLYPEPTIDE-69 is a valuable ingredient for anti-aging and skin rejuvenation, effectively boosting collagen synthesis and protecting against degradation, despite awaiting comprehensive safety assessments from major regulatory bodies.
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References
Sources