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Moumoujus

SILKWORM SH-POLYPEPTIDE-47.

Valuable / HUMECTANT, SKIN CONDITIONING

SILKWORM SH-POLYPEPTIDE-47 is a bio-engineered recombinant human peptide, precisely synthesized by silkworms to mimic human Collagen Alpha 1. It functions as a potent skin conditioning agent and humectant, supporting the skin's extracellular matrix and moisture retention.

Summary

skin conditioning humectant anti-aging

Science

Mechanism of Action

This single-chain peptide is designed to signal the skin's endogenous repair mechanisms, promoting the regeneration of mature skin and reinforcing its structural integrity. By imitating natural collagen fragments, it is believed to contribute to a visible reduction in wrinkle appearance. Additionally, it acts as a humectant, drawing and retaining water to maintain skin hydration and product stability.

Research

Clinical Evidence

Low confidence
Effective range 0.1–1%
Optimal

N/A

Key findings

  1. 01 Formulated within water-based cosmetic blends at typical use concentrations ranging from 0.1% to 1%, where it contributes to skin conditioning.
  2. 02 When incorporated into the complex ingredient Nicotiana Benthamiana Hexapeptide-40 Sh-Polypeptide-47, it has been reported to effectively reduce the length and depth of wrinkles. This observation relates to the complex ingredient's overall efficacy, not solely SILKWORM SH-POLYPEPTIDE-47.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Peptides are generally sensitive to extreme pH levels. Research suggests related silk fibroin components maintain activity effectively around a neutral pH of 7.

Synergies

  • Often integrated into water-based cosmetic blends, frequently alongside ingredients such as glycerin, xanthan gum, and standard preservatives (e.g., sodium benzoate, citric acid, potassium sorbate) for enhanced formulation stability and comprehensive skin benefits.
  • Identified as a component within complex anti-aging ingredients that have demonstrated efficacy in reducing wrinkles, suggesting synergistic actions with other peptides and active compounds.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

SILKWORM SH-POLYPEPTIDE-47 has not been specifically reviewed by name by the Cosmetic Ingredient Review (CIR) Expert Panel. While general silk proteins have often been deemed safe for cosmetic applications with typically low risks of irritation or sensitization, rare cases of contact urticaria due to silk have been documented. No specific safety opinion from the SCCS has been issued for this ingredient, and the FDA does not pre-approve cosmetic ingredients.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

SILKWORM SH-POLYPEPTIDE-47 is a valuable ingredient for its demonstrated skin conditioning and humectant properties, coupled with a promising mechanistic basis for supporting skin structure and potentially reducing wrinkle appearance, although direct clinical efficacy data for the standalone ingredient remains limited.

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