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Moumoujus

SIGESBECKIA ORIENTALIS EXTRACT.

Valuable CAS 90106-87-9 / SKIN CONDITIONING, TONIC

Sigesbeckia Orientalis Extract is a versatile botanical active ingredient acclaimed for its comprehensive skin-enhancing properties. It actively calms irritation, reduces redness, and promotes skin regeneration while stimulating collagen production for improved elasticity and firmness. This extract addresses multiple concerns, supporting overall skin health from anti-aging to the appearance of stretch marks and dark circles.

Summary

Skin conditioning Tonic Anti-inflammatory Antioxidant Collagen boosting Skin firming Anti-aging Skin regeneration Microcirculation improvement Redness reduction Elasticity enhancement

Science

Mechanism of Action

This extract functions as a sophisticated skin conditioning agent and tonic. Its anti-inflammatory prowess stems from inhibiting key inflammatory mediators by suppressing MAPKs- and NF-κB-dependent pathways, effectively reducing redness and discomfort. Sigesbeckia Orientalis also stimulates collagen synthesis, leading to enhanced skin elasticity, diminished fine lines and wrinkles, and improved skin density. Furthermore, it aids in skin regeneration, improves local blood circulation to help mitigate vascular dark circles, and offers antioxidant protection, contributing to anti-aging and rejuvenation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In an in vitro study using LPS-induced RAW264.7 macrophage cells, this concentration significantly inhibited inflammatory responses, reducing IL-6 production by 84% and TNF-α production by 58%.
  2. 02 In BV2 microglia cells, this concentration maintained greater than 75% cell viability, indicating non-cytotoxic levels, while 250 µg/mL exhibited significant cytotoxicity.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Sigesbeckia Orientalis Extract is permitted for use in cosmetics and personal care products in Europe under the general provisions of the Cosmetics Regulation. In the USA, product safety must be substantiated prior to marketing. In vitro studies demonstrate non-cytotoxicity up to 125 µg/mL, though significant cytotoxicity was observed at 250 µg/mL in specific cell lines. Oral non-toxicity in rats has also been reported.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Sigesbeckia Orientalis Extract is a valuable multi-functional botanical ingredient that effectively calms sensitive skin, reduces inflammation, and promotes collagen production for a visibly rejuvenated and firmer complexion.

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