Science
Mechanism of Action
This extract exerts its effects primarily as an anti-inflammatory agent by inhibiting NF-κB activation, suppressing COX-2 expression, and reducing the production of key inflammatory mediators such as IL-6, IL-8, nitric oxide (NO), and MCP-1. Concurrently, it offers antioxidant protection by neutralizing free radicals. Functioning as a procollagen ingredient, it aids in maintaining skin's natural collagen framework. Furthermore, in vitro studies suggest its ability to influence skin pigmentation by inhibiting melanogenesis and melanosome transport mechanisms.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
No data regarding specific 'dusting' properties or thresholds for Sigesbeckia Glabrescens Extract was available in the provided research, suggesting it is not typically considered a 'dusted' ingredient in cosmetic applications.
The Formula
Formulation
Stability
Specific optimal pH range or stability data for Sigesbeckia Glabrescens Extract were not detailed in the research provided.
Safety
Safety Profile
Sigesbeckia Glabrescens Extract has not undergone specific safety assessment by the CIR (Cosmetic Ingredient Review) or SCCS (Scientific Committee on Consumer Safety). However, botanical ingredients, and related species such as Sigesbeckia Orientalis Extract, are generally considered mild and safe for cosmetic use with a history of traditional application and are accepted under general provisions of the EU Cosmetics Regulation. While experimental animal studies reported potential pulmonary toxicity for water extracts of Siegesbeckiae Herba, no significant clinical side-effects or toxicities have been noted for the genus in general use. The EWG Skin Deep database rates Sigesbeckia Orientalis Extract with 'LOW' concern for various health risks, though it indicates that 'EWG VERIFIED products cannot contain this ingredient without adequate substantiation'.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Sigesbeckia Glabrescens Extract is a valuable multi-functional ingredient, providing significant anti-inflammatory and antioxidant benefits, pro-collagen support, and exhibiting potential for wound healing and skin tone harmonization.
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References
Sources