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Moumoujus

SIDERITIS PERFOLIATA FLOWER/LEAF/STEM EXTRACT.

Valuable / ANTIOXIDANT

This botanical extract demonstrates multi-functional potential for skin, primarily through its noteworthy elastase inhibitory activity which suggests a role in minimizing wrinkle appearance. It also provides antioxidant protection and helps address hyperpigmentation via tyrosinase inhibition.

Summary

Anti-aging Antioxidant Brightening Antibacterial Skin Elasticity

Science

Mechanism of Action

Sideritis perfoliata extract operates through multiple pathways, leveraging its antioxidant, antibacterial, and elastase inhibitory properties. The inhibition of elastase, an enzyme that degrades elastin, points to its potential in maintaining skin elasticity and reducing the visible signs of aging. Furthermore, its ability to inhibit tyrosinase suggests an action against hyperpigmentation, while its antioxidant capacity helps protect the skin from oxidative stress. These biological activities are attributed to the rich presence of flavonoids and phenols within the extract.

Research

Clinical Evidence

Medium confidence
Effective range 3.13–1000%
Optimal

N/A

Key findings

  1. 01 In vitro studies indicate significant elastase inhibitory activity, with an IC50 of 57.18 ± 3.22 µg/mL, suggesting a role in reducing the appearance of wrinkles.
  2. 02 Further elastase inhibition was observed across a concentration range from 3.13 to 250 µg/mL.
  3. 03 The extract exhibits moderate antioxidant potential and demonstrates an inhibitory effect on mushroom tyrosinase, which can be beneficial for addressing hyperpigmentation.
  4. 04 Antibacterial activity against Prevotella intermedia was noted in concentrations ranging from 15.6 to 1000 µg/mL.

Transparency

Dusting Analysis

Not commonly dusted

There is insufficient data within the provided research to determine if Sideritis Perfoliata Flower/Leaf/Stem Extract is commonly 'dusted' or to establish a dusting threshold.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The active compounds within Sideritis perfoliata extract appear to be soluble in both water and alcohol-based systems, as both ethanolic and aqueous extracts have demonstrated biological activity.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessments from CIR, SCCS, or FDA were identified for Sideritis Perfoliata Flower/Leaf/Stem Extract. While CIR has reviewed other botanical extracts and deemed them safe under specific conditions, direct safety data for this particular extract is currently absent.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Sideritis Perfoliata Flower/Leaf/Stem Extract shows valuable potential in anti-aging, antioxidant, and brightening formulations due to promising in vitro studies, though further human clinical and safety data are needed for comprehensive assessment.

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