Science
Mechanism of Action
This extract exerts its dermatological benefits through a rich composition of bioactive compounds, including alkaloids, flavonoids, tannins, and saponins. These constituents confer antioxidant activity by neutralizing free radicals, reduce inflammation pathways, and inhibit the proliferation of various microbes. Its inherent astringent qualities further contribute to skin conditioning and facilitate the repair of external skin imperfections.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Antioxidant activity was evidenced in DPPH scavenging assays with an IC50 of 50 µg/mL and in ABTS experiments with an IC50 of 16.07 mg/mL.
- 02 Significant anti-inflammatory effects were observed in rats following an oral administration of 600 mg/kg of the aerial part extract.
- 03 Demonstrated antibacterial efficacy against Gram-positive bacteria, including Staphylococcus aureus and Bacillus subtilis, with inhibition zones ranging from 10-16 mm at concentrations of 5 and 20 mg/ml. Methanol leaf and root extracts also showed significant antibacterial activity, producing inhibition zones of 12-18 mm against B. subtilis, E. coli, P. fluorescens, S. aureus, and Xanthomonas axonopodis pv. Malvacearum at a concentration of 100 g/ml.
- 04 A topically applied ethanolic extract ointment effectively stimulated wound contraction and enhanced the tensile strength of excision, incision, and burn wounds in rats.
Transparency
Dusting Analysis
Sida Cordifolia Root Extract is incorporated for its multifaceted biological activities rather than as a 'dusting' ingredient. Its diverse benefits suggest a role as a genuine active, typically used at levels contributing to functional efficacy.
The Formula
Formulation
Stability
No specific optimal pH range for stability has been identified. However, methanol extracts have shown stability when stored at 4 °C.
Safety
Safety Profile
Specific cosmetic safety assessments by regulatory bodies such as CIR, SCCS, or FDA for SIDA CORDIFOLIA ROOT EXTRACT are not readily available. Dermal toxicity is 'Not determined'. Concerns regarding ephedrine content are primarily associated with oral consumption and potential overdose, which may lead to systemic effects like hypertension and anxiety. Acute toxicity testing in rats, however, revealed no mortality or behavioral abnormalities at oral doses up to 2000 mg/kg body weight for methanol root extract, suggesting a favorable acute toxicity profile in animal models for internal use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Sida Cordifolia Root Extract is a versatile botanical offering antioxidant, anti-inflammatory, and antimicrobial benefits with wound healing potential, making it a valuable optional addition to formulations targeting these specific properties, pending more comprehensive cosmetic safety and human topical efficacy data.
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