Science
Mechanism of Action
This peptide operates via a dual-action mechanism. Primarily, as an analog of human Leu-Enkephalin, it mimics endorphin activity by interacting with delta-opioid receptors at the neuromuscular junction. This interaction hyperpolarizes the presynaptic neuron, consequently inhibiting acetylcholine release and leading to the relaxation of mimic muscles, which visibly reduces expression lines and deep wrinkles. Secondarily, it exhibits Epidermal Growth Factor (EGF)-like properties, stimulating cellular regeneration, enhancing skin texture, resilience, and fortifying the skin's barrier function. Its regenerative capacity also aids in the repair of damaged skin by encouraging cell migration.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
Based on its established mechanism and observed clinical outcomes, this ingredient is unlikely to be included merely for 'dusting' purposes, but rather for its intended active effects.
The Formula
Formulation
Synergies
- Conjugated Linoleic Acid
- Glutathione
Safety
Safety Profile
Suppliers report the ingredient is free of heavy metals and does not induce skin or eye irritation. No known side effects have been reported when used in cosmetic formulations.
Your Skin
Skin Compatibility
Our Assessment
Verdict
With a scientifically validated dual mechanism targeting muscle relaxation and epidermal regeneration, SHIKIMOYL SH-PENTAPEPTIDE-5 is a valuable peptide for comprehensive anti-aging and skin health formulations.
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References
Sources