Science
Mechanism of Action
This synthetic peptide functions as a specific agonist for delta opioid receptors in the skin, actively preventing their depletion under inflammatory conditions. This action modulates the expression of genes and proteins essential for epidermal integrity and robust barrier function, thereby mitigating skin inflammation and improving epidermal differentiation. It also reduces the impact of chronological stress aging and environmental aggressors like cigarette smoke. The peptide stimulates the regeneration of mature skin, reinforces structural components, and visibly diminishes wrinkles by activating the body’s endogenous repair mechanisms and stimulating collagen production.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 Studies on healthy volunteers confirm its efficacy in concentrations between 0.1% and 2%, demonstrating significant reduction in transepidermal water loss (TEWL), increased hydration, and a visible decrease in wrinkles within perioral and ocular areas.
- 02 An optimal use level of 1% is recommended for water-based blends, with emerging independent research highlighting its capacity to address visible aging signs stemming from both intrinsic and extrinsic factors.
- 03 Clinical evaluations indicate Rubixyl® (Hexapeptide-48 HCl) significantly diminishes deep wrinkles and improves skin smoothness over a two-month period.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The incorporation of hydrochloric acid (HCl) to form Hexapeptide-48 HCl enhances its solubility, facilitating easier integration into diverse cosmetic formulations.
Safety
Safety Profile
Shikimoyl Hexapeptide-48 is generally considered safe for cosmetic applications when used at recommended concentrations and exhibits good tolerance across most skin types.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Shikimoyl Hexapeptide-48 is a highly valuable multi-functional peptide, delivering precise anti-aging, barrier repair, and hydrating benefits with excellent skin compatibility, making it ideal for advanced skincare formulations.
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