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Moumoujus

SH-TRIPEPTIDE-5.

Valuable / SKIN CONDITIONING

SH-TRIPEPTIDE-5, also known as Palmitoyl Tripeptide-5 or Syn-Coll, is a potent biomimetic peptide engineered for deep skin penetration. It actively stimulates collagen production and protects existing collagen, leading to enhanced skin smoothness and a significant reduction in the appearance and depth of wrinkles. Its intrinsic hydrating properties further contribute to a plumper, more youthful complexion.

Summary

Anti-aging Wrinkle Reduction Collagen Stimulation Skin Conditioning Hydration Antioxidant

Science

Mechanism of Action

SH-TRIPEPTIDE-5 functions by activating the tissue growth factor (TGF-beta) within the skin, a crucial signaling pathway for stimulating the synthesis of Type I and Type II collagen and fibronectin. This directly encourages fibroblasts, the skin's collagen-producing cells, effectively mimicking the body's natural repair mechanisms. Additionally, it helps to safeguard existing collagen from degradation by inhibiting matrix metalloproteinases (MMP1 and MMP3) enzymes. The peptide also contributes to enhanced skin hydration by promoting water retention in the dermal layers and may help to reduce melanin production through a suggested decrease in tyrosinase activity.

Research

Clinical Evidence

High confidence
Effective range 0.001–2.5%
Optimal

2.5%

Key findings

  1. 01 Reduced the appearance of wrinkles by 7% after 84 days of twice-daily use.
  2. 02 Reduced the appearance of wrinkles by 12% after 84 days of twice-daily use.
  3. 03 Showcased a 15-30% reduction in the depth of wrinkles and noticeable improvement in overall skin smoothness in a 12-week study with 60 adults.
  4. 04 Demonstrated a dose-dependent wrinkle reduction in in-vivo results.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

For optimal stability, SH-TRIPEPTIDE-5 performs best within a pH range of 5.0 to 7.0. Refrigerated storage (2-8°C / 35-46°F) is recommended to maintain its integrity, and it is typically supplied without preservatives.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel assessed Palmitoyl Tripeptide-5 within a broader 'Palmitoyl Oligopeptides' group but found the collective terminology insufficient for a complete safety evaluation due to variations in amino acid sequences. Despite this, general safety assessments indicate this peptide is considered very safe and exceptionally well-tolerated, even for sensitive skin, carrying a low risk of adverse reactions. Suppliers are noted to operate in FDA-registered and cGMP/FDA compliant facilities.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

SH-TRIPEPTIDE-5 is a valuable peptide, clinically proven to reduce wrinkle appearance and depth through robust collagen stimulation and protection, making it highly effective for targeted anti-aging formulations and suitable for all skin types.

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