Science
Mechanism of Action
This advanced peptide, often recognized as SH-Polypeptide-3 or Palmitoyl sh-Tripeptide-3 Amide, functions as an analog to human Keratinocyte Growth Factor (KGF) or Epidermal Growth Factor (EGF). Its mechanism involves fostering dermal cell adhesion, spreading, and proliferation, thereby significantly boosting the skin's natural regenerative and wound healing processes. It stimulates vital collagen and elastin production, which is crucial for reducing the appearance of fine lines and wrinkles, improving skin elasticity, and enhancing moisture retention. Furthermore, SH-TRIPEPTIDE-3 exhibits potential for skin brightening through melanin inhibition and possesses anti-inflammatory properties that help soothe irritated skin.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Studies on Palmitoyl sh-Tripeptide-3 Amide (a closely related form) at 1.2% demonstrated significant reductions in wrinkles and fine lines, concurrent with promotion of keratinocyte and dermal fibroblast growth, enhanced collagen and elastin synthesis, and initiation of overall skin repair mechanisms.
- 02 A general tripeptide, when applied twice daily around the eye zones for 4 weeks at 0.0003%, led to a 39% decrease in wrinkle length, a 23% decrease in wrinkle depth, and a 17% reduction in overall skin roughness.
- 03 In vivo studies on Tripeptide-3 (Syn-Ake), a related peptide that inhibits neurotransmitters, showed up to a 52% reduction in forehead wrinkles after 28 days of twice-daily application.
- 04 Application of Tripeptide-3 in a nanoemulsion for 28 days resulted in an approximate 20% decrease in sebum production among volunteers with oily facial skin.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
For optimal stability, peptide solutions like SH-TRIPEPTIDE-3 should be maintained within a slightly acidic pH range of 5.0 to 6.0, strictly avoiding prolonged exposure to pH values exceeding 8. Peptides containing Cysteine, Methionine, or Tryptophan are prone to oxidation and necessitate storage in an oxygen-free environment. Those with Aspartic acid, Glutamic acid, Lysine, Arginine, or Histidine absorb moisture readily, requiring desiccated, sealed containers. Peptides with N-terminal Glutamine may exhibit a reduced shelf life. To preserve integrity, minimize freeze-thaw cycles by aliquoting solutions for storage.
Safety
Safety Profile
Specific safety assessments by CIR, SCCS, or FDA for SH-TRIPEPTIDE-3 or SH-Polypeptide-3 are not available in the provided data. General guidelines suggest topical peptide safety at concentrations below 10 ppm (0.001%), though this often refers to molecularly different peptides and higher concentrations (e.g., 1.2%, 4%) were used in efficacy studies for related forms. It is important to note that safety parameters can change when peptides are combined with other ingredients, and caution is advised when using on damaged skin.
Your Skin
Skin Compatibility
Our Assessment
Verdict
SH-TRIPEPTIDE-3 is a valuable regenerative peptide, offering comprehensive benefits including anti-aging, firming, wound healing, and sebum control, supported by studies on itself and closely related tripeptide forms.
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References
Sources