Science
Mechanism of Action
Operating as a fibroblast growth factor (FGF) agonist, SH-TRIPEPTIDE-1 penetrates the dermal layer to engage with FGF receptors. This interaction promotes the proliferation and differentiation of keratinocytes and dermal fibroblasts, essential cellular components for healthy skin. Its activity extends to activating ERK1/2 and Akt signaling pathways, vital for cellular proliferation, differentiation, and survival, while concurrently stimulating neo-angiogenesis to enhance microcirculation and boost collagen and elastin synthesis.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 Clinical investigations at concentrations of 1-2% demonstrate SH-TRIPEPTIDE-1's capacity to rejuvenate skin, significantly enhancing tone and texture. Studies highlight its effectiveness in boosting skin regeneration, increasing collagen and elastin production, and visibly reducing wrinkle depth. Furthermore, it stimulates the formation of new blood vessels, substantially improving blood microcirculation within the skin.
Transparency
Dusting Analysis
No specific data regarding dusting or formulation challenges related to powder dispersion for SH-TRIPEPTIDE-1 was identified in the available research.
The Formula
Formulation
Stability
The optimal pH range for SH-TRIPEPTIDE-1 stability is between 4.0 and 6.5, a range suggested by studies on related palmitoyl tripeptides. While the base peptide exhibits water solubility, palmitoylation (as observed in Palmitoyl sh-Tripeptide-1 Amide) significantly increases oil solubility and enhances skin penetration, facilitating versatile formulation options.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has not explicitly reviewed SH-TRIPEPTIDE-1 (Palmitoyl sh-Tripeptide-1 Amide), which is derived from FGF-1. While other Tripeptide-1 variations (e.g., glycine-histidine-lysine) and related peptides have been deemed safe at concentrations typically below 10 ppm, this specific ingredient has not yet undergone independent safety assessment by CIR.
Your Skin
Skin Compatibility
Our Assessment
Verdict
SH-TRIPEPTIDE-1 offers significant regenerative and anti-aging benefits through its unique mechanism of action, making it a valuable active ingredient for advanced skincare, pending further independent safety evaluations for this specific peptide.
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References
Sources