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Moumoujus

SH-TETRAPEPTIDE-2.

Essential / SKIN CONDITIONING

SH-TETRAPEPTIDE-2 is a biomimetic peptide engineered to mimic the youth hormone thymopoietin, actively working to revitalize mature skin. It precisely targets the restoration of skin firmness and elasticity by stimulating vital structural proteins and enhancing cellular cohesion.

Summary

skin-conditioning anti-aging collagen synthesis stimulation elastin synthesis stimulation fibrillin synthesis stimulation skin firming elasticity enhancement anti-sagging extracellular matrix support skin barrier strengthening antioxidant (potential) pigmentation reduction (potential)

Science

Mechanism of Action

This advanced peptide operates as a biomimetic enzyme inhibitor, directly compensating for the age-related decline of thymopoietin, a critical youth hormone. It stimulates the de novo synthesis of key structural components such as collagen, fibrillin, and elastin, while also ensuring their correct assembly within the extracellular matrix (ECM). Furthermore, SH-TETRAPEPTIDE-2 actively prevents collagen degradation and enhances the crucial adhesion between skin cells and the ECM. By promoting keratinocyte activity and proliferation, it contributes to a stronger skin barrier. Its action extends to inducing the expression of Fibulin 5 and Lysyl Oxidase-Like 1, essential for robust elastic fiber organization. Preliminary data also suggests potential antioxidant properties and an ability to modulate melanogenesis, contributing to an even skin tone.

Research

Clinical Evidence

High confidence
Effective range 0.002–0.005%
Optimal

Efficacy is observed between 0.002% and 0.005%.

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.002%
Red flag below
0.001%

SH-TETRAPEPTIDE-2 is effective at remarkably low concentrations, with clinical efficacy demonstrated between 0.002% and 0.005%. Therefore, formulating below 0.002% could indicate its inclusion is primarily for label claims rather than delivering tangible benefits.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

For optimal stability, SH-TETRAPEPTIDE-2 should be incorporated into formulations during the final manufacturing stage, ensuring temperatures remain below 45 °C. The powder form requires dry, dark storage at 0-4°C for short durations or -20°C for extended periods. Stock solutions, when prepared, should be aliquoted and stored at -80°C for up to 6 months or -20°C for 1 month, sealed tightly to prevent inactivation from moisture and repeated freeze-thaw cycles.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Generally well-tolerated across most skin types for topical cosmetic application, SH-TETRAPEPTIDE-2 is considered non-hazardous. Potential side effects are mild and may include transient skin irritation, redness, or itching. However, specific data regarding its safety during pregnancy and breastfeeding are currently unavailable, necessitating consultation with a healthcare professional.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Essential

SH-TETRAPEPTIDE-2 is an essential peptide for targeted anti-aging formulations, precisely addressing skin firmness, elasticity, and overall structural integrity.

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