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SH-TETRAPEPTIDE-1.

Valuable / SKIN CONDITIONING

SH-TETRAPEPTIDE-1 is a sophisticated signaling peptide recognized for its antioxidant properties and ability to stimulate key extracellular matrix components. It significantly contributes to comprehensive skin rejuvenation, targeting visible signs of aging for a smoother, firmer, and more hydrated complexion.

Skin conditioning Anti-aging Firming Elasticity enhancement Hydration support Barrier function improvement Antioxidant

Science

This peptide acts as a signaling molecule, actively stimulating the dermal synthesis of crucial extracellular matrix components, including collagen, elastin, and fibronectin. This regenerative action helps to counteract skin aging by improving texture, increasing firmness, and enhancing elasticity. Additionally, SH-TETRAPEPTIDE-1 possesses antioxidant benefits, supporting skin hydration and strengthening the skin barrier function.


Research

Medium confidence
Effective range N/A
Optimal

0.2%


Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH N/A
0 7 14

Stability

SH-TETRAPEPTIDE-1 powder should be stored sealed at -80°C for up to 2 years or -20°C for up to 1 year, protected from moisture. In solution, aliquoting and storage at -80°C for 6 months or -20°C for 1 month is recommended to prevent degradation from freeze-thaw cycles. The acetylation of the N-terminal end, as seen in Acetyl sh-Tetrapeptide-1, is known to enhance its stability and efficacy in cosmetic applications.


Safety

CIR Status
Not reviewed
Sensitization risk Low

Acetyl sh-Tetrapeptide-1 is broadly considered safe for use in cosmetic and personal care products under standard use and regulatory guidelines. Individuals with pre-existing allergies to peptides or exceptionally sensitive skin should exercise caution.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Valuable

SH-TETRAPEPTIDE-1 is a valuable peptide for anti-aging formulations, demonstrating clinically supported improvements in skin texture, firmness, and density by stimulating vital extracellular matrix components and offering antioxidant benefits across various skin types.


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