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Moumoujus

SH-SPINORPHIN SP.

Valuable CAS 137201-62-8 / SKIN PROTECTING

SH-SPINORPHIN SP is a synthetic human peptide engineered to mimic endogenous spinorphin, a natural regulator of enkephalinases. By inhibiting enzymes that break down enkephalin peptides, it aims to enhance the skin's inherent soothing and anti-inflammatory pathways. This mechanism supports skin comfort and resilience, particularly beneficial for sensitive and compromised skin.

Summary

skin-conditioning soothing anti-inflammatory

Science

Mechanism of Action

This peptide operates by precisely inhibiting a spectrum of enkephalinase enzymes, including aminopeptidase N (APN), dipeptidyl peptidase III (DPP3), angiotensin-converting enzyme (ACE), and neutral endopeptidase (NEP). By preventing the rapid degradation of endogenous enkephalin peptides, SH-SPINORPHIN SP extends their beneficial effects. This leads to demonstrable anti-inflammatory and potentially antinociceptive (pain-relieving) properties, notably through the inhibition of neutrophil activation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No data available suggests this ingredient is commonly 'dusted' at specific thresholds in cosmetic formulations.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

Optimal stability and presence in solution are observed within the pH range of 5.0-7.0, though the peptide can exist across a broader pH spectrum of 2.0-11.0. Stability can be compromised by elevated temperatures; some spinorphin analogs show partial hydrolysis at 40°C over 12 hours, with others completely degrading within 6 hours. Chemical modifications like C-terminal amides or bioconjugation are known to enhance peptide stability against enzymatic degradation.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Specific safety reviews by regulatory bodies such as CIR, SCCS, or FDA for SH-SPINORPHIN SP are not publicly available. As a synthetic human peptide, its safety in cosmetics is generally evaluated within the broader class of peptides, which typically exhibit low toxicity. However, the potential for allergic reactions in sensitive individuals cannot be entirely ruled out without specific ingredient data. The FDA does not pre-approve cosmetic ingredients.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

SH-SPINORPHIN SP is a valuable peptide for precision skincare, offering promising soothing and anti-inflammatory benefits through its ability to modulate enkephalinase activity, supporting skin comfort and resilience.

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