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Moumoujus

SH-POLYPEPTIDE-93.

Insufficient Data / SKIN CONDITIONING

SH-POLYPEPTIDE-93 is a sophisticated synthetic analog of human connective tissue growth factor (CTGF), engineered to enhance skin's natural regenerative processes. It actively stimulates collagen production, improving skin elasticity, increasing dermal thickness, and contributing to a firmer, more youthful complexion.

Summary

Skin Conditioning Anti-aging Skin Firming Anti-wrinkle Wound Healing

Science

Mechanism of Action

This ingredient functions as a 324-amino acid recombinant human CTGF analog, specifically designed to mimic the Insulin-like Growth Factor (IGF)-binding domain of endogenous CTGF. By precisely regulating gene expression within fibroblasts, it reactivates pathways responsible for collagen synthesis. Given that natural CTGF levels decline with age, topical application of SH-POLYPEPTIDE-93 aims to restore these crucial signaling functions, thereby boosting collagen, enhancing elasticity, and increasing dermal density.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Topical application of sh-Polypeptide-93 has been shown to mimic connective tissue growth factor (CTGF) action, leading to enhanced collagen production, improved skin elasticity, and increased dermal thickness, conferring skin-firming, anti-wrinkle, and wound-healing benefits.

Transparency

Dusting Analysis

Not commonly dusted

There is no available data to suggest that SH-POLYPEPTIDE-93 is commonly used at sub-efficacious concentrations or primarily for 'dusting' purposes.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

While generally described as safe and effective, the Cosmetic Ingredient Review (CIR) currently reports 'insufficient data' for SH-POLYPEPTIDE-93 specifically, having only reviewed broader categories of proteins and peptides. Paula's Choice also lists it as 'Not rated' with 'No known benefits,' indicating a lack of comprehensive, publicly available research to fully assess its safety or efficacy by their standards.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

SH-POLYPEPTIDE-93 demonstrates promising mechanistic actions and initial clinical indications for collagen stimulation and anti-aging benefits; however, comprehensive, independent safety and efficacy data remain limited, warranting further research.

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