Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

SH-POLYPEPTIDE-9.

Insufficient Data / SKIN CONDITIONING

SH-POLYPEPTIDE-9 is a synthetic recombinant analog of human Vascular Endothelial Growth Factor A (VEGFA). This potent cell-signaling protein supports the formation of new blood vessels, enhancing nutrient delivery and promoting cellular renewal for improved skin health and regeneration.

Summary

cell-signaling skin conditioning anti-aging moisturizing wound healing tissue regeneration anti-inflammatory antioxidant

Science

Mechanism of Action

As a mimic of human VEGFA, SH-POLYPEPTIDE-9 operates as a key cell signaling protein, stimulating angiogenesis—the vital formation of new microvascular networks. This process dramatically improves oxygen and nutrient supply to skin cells. It accelerates cell division and migration, boosts essential protein synthesis for tissue restructuring, and fosters the development and proliferation of new cells critical for skin formation and wound healing. Furthermore, it modulates vascular wall permeability, alleviates vascular spasms, and facilitates monocyte migration within skin layers. Its activity includes protecting endothelial cells from oxidative stress by reducing the inflammatory cytokine interleukin-1α (IL-1α) and regulating immune responses, thereby supporting tissue repair and recovery.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

Growth factors, including SH-POLYPEPTIDE-9, can be destabilized in acidic environments (e.g., formulations containing AHAs or BHAs), potentially reducing their efficacy. For optimal performance, it is advisable to apply acidic products first, allowing for a brief absorption period, before layering products containing SH-POLYPEPTIDE-9.

Conflicts

  • Alpha Hydroxy Acids (AHAs)
  • Beta Hydroxy Acids (BHAs)

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

While the CIR Expert Panel generally deems skin and connective tissue-derived proteins and peptides safe, SH-POLYPEPTIDE-9 has not been explicitly reviewed and assigned a specific safety status. The European Commission's CosIng database currently lacks an SCCS opinion for BARLEY SH-POLYPEPTIDE-9. The FDA requires cosmetic ingredients to be safe for consumer use without pre-approval. EWG Skin Deep rates this ingredient with a low hazard score, indicating minimal concerns for cancer, allergies, immunotoxicity, and developmental/reproductive toxicity. However, due to its VEGFA-like activity, individuals with psoriasis, sunburn, or recent high-dose UV exposure should avoid products containing SH-POLYPEPTIDE-9, as VEGFA can exacerbate these conditions.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Insufficient Data

While exhibiting promising mechanistic benefits for skin regeneration, anti-aging, and anti-inflammatory action with a low irritancy profile, a definitive safety verdict remains pending due to insufficient specific regulatory review for this particular peptide.

Related

Similar Ingredients

Finding similar ingredients…