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Moumoujus

SH-POLYPEPTIDE-85.

Insufficient Data / SKIN CONDITIONING

SH-POLYPEPTIDE-85 is a signaling peptide engineered to activate the skin's intrinsic repair mechanisms. It supports the synthesis of crucial structural proteins like collagen, stimulates regeneration, and strengthens skin architecture, potentially reducing the visible signs of aging and maintaining overall skin health.

Summary

Skin Conditioning Anti-aging Collagen Boosting Skin Regeneration Skin Firming Wrinkle Reduction

Science

Mechanism of Action

This polypeptide functions by signaling the body to initiate its endogenous skin repair processes. It actively promotes the production of vital proteins such as collagen, encourages cellular regeneration, enhances the skin's structural integrity, and contributes to a visible reduction in the appearance of wrinkles, thereby sustaining optimal skin condition.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Peptides, including SH-POLYPEPTIDE-85, are generally sensitive in aqueous solutions, making them susceptible to degradation pathways such as hydrolysis, deamidation, epimerization, and aggregation. Factors like temperature, pH, ionic strength, and interfacial exposure significantly influence their stability. Optimal stability can be achieved through precise pH adjustment, selection of appropriate buffer systems, use of co-solvents, air exclusion, viscosity enhancement, PEGylation, and the incorporation of polyol excipients. For larger polypeptide molecules, advanced carrier systems like liposomes or nanoparticles may be necessary to improve stability, enhance penetration into the skin, and maximize topical efficacy.

Conflicts

  • Highly acidic pH environments (1-3) which can cause acid-catalyzed hydrolysis.
  • Highly alkaline pH environments (>7) leading to base-catalyzed epimerization.
  • Specific pH ranges, such as 5-6, which may induce hydrolysis at serine residues for certain peptides.
  • Interactions with container closure systems and various excipients, which can compromise peptide stability and safety.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

While the Cosmetic Ingredient Review (CIR) Expert Panel has assessed the safety of various peptide and protein groups, SH-POLYPEPTIDE-85 has not undergone specific review or assessment in the provided summaries. It is important to note that other SH-polypeptides (e.g., SH-Polypeptide-1) have documented safety considerations, including potential associations with melanoma progression. However, this specific information cannot be directly applied to SH-POLYPEPTIDE-85 without dedicated safety data for this precise molecule.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

SH-POLYPEPTIDE-85 offers a promising mechanism for skin rejuvenation through endogenous repair; however, specific clinical efficacy data, optimal usage concentrations, and a comprehensive safety review for this particular polypeptide are currently insufficient, necessitating further research.

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