Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

SH-POLYPEPTIDE-76.

Valuable / SKIN CONDITIONING

A bio-engineered fusion peptide, SH-POLYPEPTIDE-76 serves as a potent plant-based retinoid alternative. It actively revitalizes skin by stimulating key cellular processes, leading to a visibly firmer, smoother, and more hydrated complexion.

Summary

Skin-Conditioning Agent Anti-aging Firming Plumping Hydrating Skin Barrier Support Collagen Stimulation Texture Improvement Pore Reduction

Science

Mechanism of Action

SH-POLYPEPTIDE-76, often identified as Nicotiana Benthamiana Hexapeptide-40 SH-Polypeptide-76, is a sophisticated fusion peptide produced in Nicotiana benthamiana plants. It combines Hexapeptide-40 with a recombinant human peptide engineered to mirror Transforming Growth Factor Beta-2 (TGF-β2). This unique structure enables it to act as a plant-based retinoid alternative, signaling the skin to activate its natural repair mechanisms. Specifically, it promotes fibroblast proliferation and stimulates the synthesis of type I collagen and epidermal lipids, essential for robust skin structure and barrier function, leading to enhanced skin condition, improved texture, and sustained hydration.

Research

Clinical Evidence

High confidence
Effective range 1.5–2%
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Specific data regarding 'dusting' practices or minimum effective concentrations beyond the clinical study range are not available in the provided research. Efficacy has been demonstrated within a 1.5-2% concentration range.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

This peptide demonstrates enhanced chemical stability compared to traditional retinoids, positioning it as a robust alternative suitable for both daytime and nighttime applications without degradation concerns.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Generally considered safe for topical cosmetic use, plant-based polypeptides are typically well-tolerated with a low risk of irritation or allergic reactions. EWG rates its cancer concern as 'Low', with 'unknown/unassessed' for immune effects. As with any new ingredient, a preliminary patch test is advised. Data on safe usage during pregnancy and breastfeeding is limited; professional medical consultation is recommended for these populations.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

SH-POLYPEPTIDE-76 is a valuable, bio-engineered peptide offering broad skin benefits as a stable retinoid alternative, effectively targeting signs of aging, improving barrier function, and enhancing overall skin health.

Related

Similar Ingredients

Finding similar ingredients…