Science
Mechanism of Action
This peptide functions by regulating vasodilation within skin tissue, effectively soothing inflammation and encouraging angiogenesis—the formation of new blood vessels. It supports enhanced cellular metabolism and oxygenation while facilitating the efficient removal of metabolic waste. Furthermore, SH-POLYPEPTIDE-71 stimulates the migration and proliferation of skin keratocytes, crucial for accelerating epidermal regeneration, wound healing, and fortifying the skin’s natural barrier. By signaling the body's intrinsic repair mechanisms, it contributes to overall skin health and resilience.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 At a 2% concentration, clinical studies demonstrate a significant reduction in inflammation, redness, and flakiness. This concentration was also found effective against fine lines and wrinkles after 12 weeks (in subjects aged 51) and exhibited anti-atopic effects within 8 weeks (in subjects aged 22).
- 02 Concentrations between 1-2% have been shown to promote hair growth and mitigate hair loss in specific formulations.
- 03 Ultra-low concentrations, ranging from 0.00004% to 0.00024%, have been observed to promote all stages of the anagenic (growth) phase of human hair in multi-factor hair growth formulations.
Transparency
Dusting Analysis
While SH-POLYPEPTIDE-71 shows efficacy at extremely low concentrations for hair growth, achieving significant anti-inflammatory, redness-reducing, and anti-aging benefits for skin typically requires concentrations closer to 2%. Formulations targeting these specific dermal improvements with less than 1.0% may be considered underdosed for optimal efficacy, potentially indicating 'dusting' if those are the primary claims.
The Formula
Formulation
Stability
The ingredient has been tested for stability and efficacy for a minimum of 15 months. For enhanced stability and facilitated dermal penetration, SH-POLYPEPTIDE-71 is often encapsulated in liposome-based carrier systems.
Safety
Safety Profile
As a synthetic recombinant human peptide, SH-POLYPEPTIDE-71 is intrinsically compatible with human tissues and biodegradable. This inherent biocompatibility contributes to its safety for topical application. It is designed not to penetrate the intact epidermal barrier under normal conditions, minimizing systemic exposure.
Your Skin
Skin Compatibility
Our Assessment
Verdict
SH-POLYPEPTIDE-71 is a highly valuable ingredient due to its multifaceted benefits in inflammation reduction, anti-aging, skin regeneration, and hair growth, showing excellent compatibility across all skin types.
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References
Sources