Science
Mechanism of Action
SH-POLYPEPTIDE-7 functions by mimicking human growth hormone (hGH), specifically binding to the growth hormone receptor (GHR) on fibroblasts within the skin. This activation stimulates fibroblast proliferation and upregulates the production of insulin-like growth factor-1 (IGF-1) and its binding protein IGFBP-3. The synergistic action of IGF-1 and rh-hGH promotes heightened collagen synthesis and production of other extracellular matrix components, leading to a visible reduction in the appearance of fine lines and wrinkles. SH-POLYPEPTIDE-94 and SH-POLYPEPTIDE-95, as components of a synthetic fusion peptide, act as cellular messengers, activating intrinsic repair mechanisms, stimulating regeneration, and fortifying the skin's architecture for improved firmness and reduced wrinkle depth.
Research
Clinical Evidence
Insufficient-data confidenceN/A
Transparency
Dusting Analysis
No specific data on common dusting practices or thresholds for this ingredient combination was found in the provided research.
The Formula
Formulation
Safety
Safety Profile
While the Cosmetic Ingredient Review (CIR), SCCS, or FDA has not specifically reviewed the combined ingredient, SH-POLYPEPTIDE-7 individually boasts an extensive SkinSAFE rating as 'Irritant Free' across numerous categories including common preservatives, fragrance, parabens, and dyes. Furthermore, these sh-polypeptides are noted to be intrinsically compatible with human tissues, biodegradable, and designed not to penetrate the intact epidermal barrier under normal conditions, suggesting a favorable safety profile for topical application.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This polypeptide complex presents a strong mechanistic basis for anti-aging and regenerative benefits; however, specific clinical efficacy data with quantified concentrations is not available in the provided research to definitively assess its performance.
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References
Sources