Science
Mechanism of Action
This peptide operates by significantly upregulating SIRT-1 expression within both fibroblasts and keratinocytes. This action is crucial for mitigating oxidative stress from UV-induced free radicals and oxidants. It also initiates the production of nicotinamide, deacetylated lysine, and OAADPr, which collectively reduce Reactive Oxygen Species (ROS) and boost NADPH levels, thereby protecting cells from damage. This multifaceted ingredient further supports the skin's structure by enhancing cellular communication and increasing the synthesis of key extracellular matrix components, specifically collagen and elastin.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
Specific data regarding potential dusting of SH-PENTAPEPTIDE-35 in formulations is not available within the provided research.
The Formula
Formulation
Stability
While specific stability data for SH-PENTAPEPTIDE-35 is currently unavailable, research on a model cyclic pentapeptide indicated optimal stability around pH 3.0, with observed increased degradation at higher pH levels. This suggests potential pH sensitivity in formulation.
Safety
Safety Profile
No specific safety assessments from CIR, SCCS, or FDA have been published for SH-PENTAPEPTIDE-35 or its acetylated form. However, INCIDecoder reports 'No penalty' across all categories for Acetyl SH-Pentapeptide-35, indicating a low likelihood of significant safety concerns for cosmetic use based on available general data.
Your Skin
Skin Compatibility
Our Assessment
Verdict
SH-PENTAPEPTIDE-35 is a valuable peptide due to its comprehensive mechanistic benefits in anti-aging and antioxidant defense, though specific human clinical efficacy data with quantified percentages is not yet available.
Related
Similar Ingredients
Finding similar ingredients…