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Moumoujus

SH-PENTAPEPTIDE-3.

Valuable / SKIN CONDITIONING

SH-Pentapeptide-3 is a precision-engineered synthetic peptide (Val-Ser-Gly-Ile-Arg) designed to enhance the skin's structural integrity. It actively supports the synthesis of key extracellular matrix proteins like collagen and elastic fibers, aiming to improve firmness, reduce visible signs of aging, and promote a more even skin tone.

Summary

Cell-communicating ingredient Skin-identical ingredient Anti-aging Collagen boosting Elastin boosting Skin firming Elasticity enhancement Moisture retention Skin brightening Anti-inflammatory Wound healing

Science

Mechanism of Action

This potent pentapeptide functions as a cell-communicating and skin-identical ingredient. Its primary mechanism involves positively influencing the synthesis of Microfibril-associated glycoprotein 4 (MFAP-4), a crucial regulator in the organization of elastin and the formation of robust elastic fibers. Simultaneously, SH-Pentapeptide-3 stimulates overall collagen and elastin production, contributing to improved skin architecture and resilience. Beyond these foundational actions, it is described to visibly diminish fine lines and wrinkles, enhance skin firmness and elasticity, support optimal moisture retention, brighten skin tone through melanin inhibition, and possess anti-inflammatory and wound healing properties.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

For optimal stability during storage, solutions containing SH-Pentapeptide-3 are generally best maintained at a slightly acidic pH, typically ranging between 5 and 6. To preserve its integrity during formulation, incorporation into cosmetic products should ideally occur at temperatures below 40°C.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically evaluated SH-PENTAPEPTIDE-3. However, related pentapeptides, such as Myristoyl Pentapeptide-4, Palmitoyl Pentapeptide-4, and Pentapeptide-4 (KTTKS and KTSKS sequences), have been deemed safe for use in cosmetics by the CIR. The FDA typically does not pre-approve individual cosmetic ingredients.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

SH-PENTAPEPTIDE-3 is a valuable peptide, offering a multi-faceted approach to skin rejuvenation through its detailed mechanism of promoting collagen and elastin synthesis, making it beneficial for anti-aging and overall skin health.

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