Science
Mechanism of Action
Functioning as a single-chain human peptide, SH-Pentapeptide-2 is created to be structurally identical to a specific portion of the elastin protein. Comprising five amino acids—glycine, proline, and valine—it is believed to act by mimicking natural elastin fragments, thereby potentially enhancing the skin's natural elastic properties and structural support.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Peptide stability is sequence-dependent. For optimal shelf-life, lyophilized forms are typically stored at -20 °C. Once in solution, storage in aliquots at -20 °C or preferably -80 °C is recommended to prevent degradation from repeated freeze-thaw cycles. Peptides with methionine, cysteine, or tryptophan may require oxygen-free conditions to inhibit oxidation. Dissolution is generally favorable at near-neutral pH (6-8), though optimal stability pH can vary significantly between different peptide structures.
Conflicts
- Certain preservatives, specifically phenylethyl alcohol, chlorobutanol, benzalkonium chloride, and benzyl alcohol, can induce conformational changes and aggregation in peptides, potentially increasing immunogenicity or allergic reactions.
- Interactions with polysorbate micelles (e.g., Tween 80) have been noted to potentially induce antibodies.
- Both extreme pH levels and high temperatures are detrimental, leading to peptide degradation.
- Peptides containing free cysteine residues should be dissolved in degassed acidic buffers to prevent rapid oxidation if the pH exceeds 7.
Safety
Safety Profile
This ingredient has not been directly reviewed by CIR or SCCS, and no specific FDA status for SH-PENTAPEPTIDE-2 as a cosmetic ingredient was identified. Safety profiles for peptides are often assessed as broader categories rather than individually.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While conceptually promising as an elastin mimetic, SH-PENTAPEPTIDE-2 lacks specific clinical efficacy and comprehensive safety data to confidently assess its performance and suitability in formulations.
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