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Moumoujus

SH-PENTAPEPTIDE-1.

Valuable CAS - / SKIN CONDITIONING

SH-PENTAPEPTIDE-1 is a synthetic biomimetic peptide derived from thymopoietin, a human immunomodulatory hormone. It is specifically engineered to soothe sensitive skin, mitigate irritation, and bolster the skin's inherent defense mechanisms.

Summary

skin conditioning immunomodulator anti-inflammatory soothing anti-psoriasis

Science

Mechanism of Action

This peptide functions as an immunomodulator, primarily by regulating the skin's microflora, influencing helper T-cell proportions, and actively diminishing inflammation through the suppression of interleukins, particularly IL-17. Its acetylated derivative, Acetyl sh-Pentapeptide-1, further enhances these effects by calming sensitive skin, combating irritation, reinforcing natural defenses against infections, and inhibiting detrimental enzymes like IL-8 and matrix metalloproteinases (MMPs, especially MMP-9) to preserve structural proteins such as collagen and elastin.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Clinical evaluations suggest promising results in reducing irritation and soothing sensitive skin. Further research indicates its potential for managing inflammatory skin conditions, including psoriasis and severe atopic dermatitis, as highlighted in studies on thymopentin and thymopentapeptide's dermatological applications.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Peptides generally demand meticulous formulation. It is crucial to avoid interactions with specific preservatives such as phenylethyl alcohol, chlorobutanol, benzalkonium chloride, and benzyl alcohol, as well as certain polysorbates like Tween 80, which can induce conformational changes, aggregation, and potential immunogenicity. Maintaining sterility and utilizing oxygen-free water or buffer solutions (e.g., Tris or phosphate at pH 7) are recommended for peptide solutions, with sonication aiding dissolution and minimizing aggregation.

Conflicts

  • phenylethyl alcohol
  • chlorobutanol
  • benzalkonium chloride
  • benzyl alcohol
  • polysorbates (e.g., Tween 80)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No specific safety assessments from CIR, SCCS, or FDA have been identified for SH-PENTAPEPTIDE-1. The FDA UNII for this compound is O3Y80ZF13F.

Your Skin

Skin Compatibility

Yes Normal
No Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

SH-PENTAPEPTIDE-1 is a valuable immunomodulating peptide for precision skincare, offering significant anti-inflammatory and soothing benefits particularly for sensitive and irritated skin, while protecting structural proteins.

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