Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

SH-OLIGOPEPTIDE-85.

Valuable / NOT REPORTED

SH-Oligopeptide-85 is a bioengineered polypeptide, closely related to Epidermal Growth Factor (EGF), that acts as a potent cellular signal to promote skin cell growth, regeneration, and the synthesis of vital extracellular matrix components for improved skin health and appearance.

Summary

cell-communicating ingredient wound healing anti-aging skin regenerating collagen boosting improves skin elasticity reduces fine lines and wrinkles improves skin tone and texture brightening

Science

Mechanism of Action

This ingredient functions as a cellular signal molecule, stimulating accelerated skin cell division, growth, and differentiation. It significantly enhances the production and secretion of essential extracellular macromolecules like hyaluronic acid and glycoproteins. By boosting keratinocyte expression and growth, it aids in wound healing, increases collagen synthesis, and strengthens the skin's natural barrier function, leading to comprehensive skin revitalization.

Research

Clinical Evidence

Medium confidence
Effective range 0.2–20%
Optimal

N/A

Key findings

  1. 01 A 2012 study using a serum containing a bioengineered epidermal growth factor demonstrated statistically significant improvements in the appearance of fine lines, wrinkles, skin texture, pore size, and various dyschromatic conditions within one month, with sustained improvements over three months. This study also noted enhanced skin regeneration, wrinkle reduction, and improved skin tone through stimulated collagen production, firmness, and elasticity.
  2. 02 A manufacturer-sponsored clinical trial observed notable increases in skin elasticity, luminosity, and brightness, alongside a reduction in skin sagging after 30 days of using a product containing sh-oligopeptide-1. However, this study acknowledged imprecise methods and the absence of a properly defined control group.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

This ingredient, when formulated as SpecBio™EGF Plus (CE85), exhibits good stability at room temperature, eliminating the need for cold storage. It should be incorporated into formulations during the final step at temperatures below 45℃ to maintain its integrity.

Safety

Safety Profile

CIR Status
Unknown
Sensitization risk Low

SH-Oligopeptide-1 (often used interchangeably in research with SH-Oligopeptide-85) is generally considered safe, compatible, and biodegradable for cosmetic use in various concentrations. While it is mitogenic (stimulates cell proliferation), it is not recognized as mutagenic (does not cause cancerous cell alterations). However, long-term risks remain unknown. Caution is advised for individuals with existing skin cancer risk factors or psoriasis, as EGF could potentially accelerate cancer cell spread or exacerbate psoriasis. Active recombinant human EGF (hr-EGF) is not authorized as a medication in topical applications outside of clinical trials, classifying it as a potent unauthorized drug in some contexts.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

SH-Oligopeptide-85 is a valuable ingredient, demonstrated to significantly improve multiple signs of aging and promote skin regeneration, though its long-term safety and regulatory status warrant careful consideration.

Related

Similar Ingredients

Finding similar ingredients…