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Moumoujus

SH-OLIGOPEPTIDE-72.

Valuable / SKIN CONDITIONING

SH-OLIGOPEPTIDE-72 is a synthetic biomimetic peptide designed to support advanced skin rejuvenation. It actively enhances the proliferation and function of key skin cells, including keratinocytes and mesenchymal stem cells, while also working to preserve the skin's natural hyaluronic acid. This multifaceted approach aims to improve hydration, elasticity, and overall skin youthfulness.

Summary

Skin Conditioning Anti-aging Hydration Enhancement Elasticity Improvement Skin Rejuvenation Wound Healing Support

Science

Mechanism of Action

This synthetic biomimetic peptide signals the skin to activate its intrinsic repair mechanisms. SH-OLIGOPEPTIDE-72 significantly boosts the proliferation and morphological changes of dermal fibroblasts, demonstrating an increase in fibroblast activity by up to four times. It functions as an antagonist to the hyaluronidase enzyme, thereby protecting hyaluronic acid molecules from degradation, which consequently enhances skin hydration, volume, and elasticity, and visibly smooths fine lines. Furthermore, it stimulates the division and differentiation of skin stem cells and mobilizes the metabolic and migratory activity of mesenchymal stem cells (MSCs) within the human dermis and hypodermis, contributing to the expansion of a youthful fibroblast pool.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No information suggests this ingredient is commonly 'dusted' in formulations; efficacy is observed at specific concentrations in in vitro studies.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

Specific data regarding solubility, optimal pH range, or stability notes for SH-OLIGOPEPTIDE-72 is not available.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

SH-OLIGOPEPTIDE-72 has not undergone specific safety assessment by regulatory bodies such as CIR, SCCS, or FDA. While general CIR reviews exist for broader categories of 'Tissue-Derived Proteins and Peptides' and 'Ectodermal-Derived Proteins and Peptides' concluding safety for reviewed ingredients, SH-OLIGOPEPTIDE-72 is not explicitly listed. There are general concerns regarding some cosmetic peptides lacking robust preclinical bioactivity and long-term risk data, as noted for a different peptide (SH-OLIGOPEPTIDE-1).

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

SH-OLIGOPEPTIDE-72 presents as a valuable active ingredient with promising in vitro data supporting its role in cellular rejuvenation, hydration, and repair, though further human clinical and safety data would strengthen its profile.

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