Science
Mechanism of Action
This peptide functions by mimicking Insulin-like Growth Factor 1 (IGF-1), stimulating cell proliferation and aiding in wound healing pathways. It is believed to act synergistically with Epidermal Growth Factor (EGF, or SH-Oligopeptide-1) to enhance keratinocyte proliferation, thereby contributing to overall skin regeneration, reduction of fine lines, improved scar healing, and increased hydration through optimized cell growth and differentiation.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
Specific effective concentrations or comprehensive clinical data for SH-Oligopeptide-70 are not available, making it difficult to assess if it is commonly used at sub-efficacious percentages. However, no direct evidence suggests it is frequently 'dusted' in formulations.
The Formula
Formulation
Stability
While specific stability data for SH-Oligopeptide-70 is not detailed, related growth factors like SH-Oligopeptide-1 (EGF) are highly unstable, often requiring storage at -20°C in laboratory settings. Estimates suggest only 5-10% of their activity may remain at room temperature in cosmetic products, indicating significant stability challenges that could impact the shelf life and functional efficacy of SH-Oligopeptide-70 in formulations.
Synergies
- Epidermal Growth Factor (EGF / SH-Oligopeptide-1) for enhanced keratinocyte proliferation.
Safety
Safety Profile
Specific safety assessments (e.g., CIR, SCCS, FDA) for SH-Oligopeptide-70 are not readily available. General concerns exist for growth factors and peptides due to their mitogenic activity (ability to increase cell numbers), advising caution for individuals with conditions such as psoriasis or elevated skin cancer risk. The long-term risks of this ingredient in cosmetic applications remain undefined, mirroring concerns about the lack of scientific basis for clinical claims and unknown long-term effects of related growth factors like SH-Oligopeptide-1, despite the CIR Expert Panel reviewing other peptides generally as safe without explicitly listing SH-Oligopeptide-70.
Your Skin
Skin Compatibility
Our Assessment
Verdict
SH-Oligopeptide-70 offers a theoretically promising mechanism for skin regeneration through IGF-1 signaling; however, robust scientific evidence regarding its specific cosmetic efficacy and long-term safety profile is currently insufficient.
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