Science
Mechanism of Action
Upon topical application, SH-Oligopeptide-5 engages specific cell surface receptors, activating crucial cellular communication pathways for skin repair and regeneration. It stimulates human dermal fibroblast growth and collagen synthesis, leading to improved skin firmness, smoothness, and elasticity. Furthermore, it promotes the release of Keratinocyte Growth Factor (KGF), accelerating skin cell renewal and facilitating the desquamation of pigmented keratinocytes, which contributes to a brighter, more even skin tone. This action collectively optimizes extracellular matrix dynamics and supports robust dermal repair.
Research
Clinical Evidence
High confidence0.5-3.0%
Key findings
- 01 Clinical data indicates that at concentrations of 0.5-3.0% in final skincare products, SH-Oligopeptide-5 effectively supports collagen production, visibly improves skin elasticity, and enhances hydration.
- 02 In high-performance skincare, formulations incorporating SH-Oligopeptide-5 (from a 1.0-10% stock solution) promote intensive repair, advanced anti-aging effects, robust dermal repair, and noticeable texture improvement.
Transparency
Dusting Analysis
Clinical studies demonstrate efficacy for SH-Oligopeptide-5 when used at concentrations between 0.5% and 3.0% in final skincare formulations. Concentrations below 0.5% are considered sub-optimal and are unlikely to yield the clinically observed benefits.
The Formula
Formulation
Stability
SH-Oligopeptide-5 remains stable in aqueous solutions within a pH range of 5.0 to 7.0. To preserve its bioactivity, avoid extreme pH values and high temperatures. It should be incorporated into the water phase during the cool-down stage of formulation, specifically at temperatures below 40°C.
Synergies
- Demonstrates synergistic benefits when combined with sh-Oligopeptide-1 (EGF) and various Fibroblast Growth Factors for enhanced repair and anti-aging outcomes.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has assessed broader categories of 'Tissue-Derived Proteins and Peptides' and 'Ectodermal-Derived Proteins and Peptides,' concluding their safety under current use. However, SH-Oligopeptide-5 specifically lacks a dedicated individual CIR safety assessment. There is no explicit FDA or SCCS status available for this peptide. While SH-Oligopeptide-1 (EGF) is approved in European cosmetics, SH-Oligopeptide-5 is a distinct molecule.
Your Skin
Skin Compatibility
Our Assessment
Verdict
SH-Oligopeptide-5 is a highly valuable bioactive peptide, demonstrating robust efficacy in promoting collagen synthesis, enhancing elasticity, and accelerating skin renewal for advanced anti-aging and reparative skincare, though specific individual safety data is not extensively documented.
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