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Moumoujus

SH-OLIGOPEPTIDE-4.

Valuable / SKIN CONDITIONING

SH-OLIGOPEPTIDE-4 is a synthetic recombinant peptide derived from Thymosin-β4, offering comprehensive rejuvenating benefits for the skin. It actively enhances skin elasticity, reduces the appearance of wrinkles, and significantly improves moisture levels, alongside robust antioxidant and reparative actions.

Summary

Skin Conditioning Anti-aging Antioxidant Moisturizing Firming Hair Growth Promoter Wound Healing Dark Spot Reduction Acne Management

Science

Mechanism of Action

This peptide operates by stimulating collagen deposition and accelerating natural wound recovery processes. At a cellular level, it efficiently neutralizes Reactive Oxygen Species (ROS) and ABTS free radicals, concurrently enhancing Superoxide Dismutase (SOD) activity for superior antioxidant defense. SH-OLIGOPEPTIDE-4 also stabilizes mitochondrial membrane potential, boosting ATP energy production and improving mitochondrial function. It actively counters collagen degradation from UVA exposure, stimulates Extracellular Matrix (ECM) regeneration, and protects against photoaging. Beyond skin, it promotes hair growth by stimulating follicle stem cell growth, migration, differentiation, and protease production.

Research

Clinical Evidence

High confidence
Effective range 2–10%
Optimal

N/A

Key findings

  1. 01 Significantly improves overall skin condition, smooths wrinkles, enhances skin elasticity, provides anti-aging effects, and boosts skin's moisture content. It also helps in combating dark spots and acne.
  2. 02 Effectively scavenges free radicals, improves mitochondrial function, increases cellular energy, and delivers anti-oxidative stress, anti-wrinkle, and firming effects.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

For optimal stability and integrity, SH-OLIGOPEPTIDE-4 should be incorporated into formulations at temperatures below 40°C.

Conflicts

  • strong acids
  • strong bases
  • protein denaturants

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While the Cosmetic Ingredient Review (CIR) has not yet assessed SH-OLIGOPEPTIDE-4, it is listed in the European Commission's CosIng database as a skin conditioning agent. SkinSAFE identifies it as 'Irritant Free', and The Good Scents Company reports no GHS hazards. However, specific oral, dermal, and inhalation toxicity data are currently undetermined.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

SH-OLIGOPEPTIDE-4 is a valuable multi-functional peptide, demonstrating significant anti-aging, antioxidant, and restorative benefits, making it suitable for diverse skin types and concerns, including potential hair growth applications.

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