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Moumoujus

SH-OLIGOPEPTIDE-2.

Valuable / SKIN CONDITIONING, SKIN PROTECTING

SH-Oligopeptide-2 is a synthetic polypeptide, a 70-amino acid analog of the naturally occurring Insulin-like Growth Factor-1 (IGF-1). It acts as a powerful signaling molecule, orchestrating cellular regeneration and proliferation within the skin.

Summary

Cell-communicating ingredient Skin-identical ingredient Anti-aging Wound healing support Collagen production stimulant Hyaluronic acid booster Skin regeneration promoter Barrier strengthening Elasticity improvement Fine line and wrinkle reduction UVB protection

Science

Mechanism of Action

This advanced synthetic peptide mimics the critical functions of natural IGF-1, primarily by activating the AKT signaling pathway, which is essential for cellular regeneration, anti-aging processes, and accelerating wound healing. Topically, it stimulates the biosynthesis of vital extracellular matrix components, including hyaluronic acid and collagen, leading to enhanced skin smoothness, elasticity, and firmness. Its action contributes to a visible reduction in fine lines, deep wrinkles, and blotchiness, alongside fostering new blood vessel formation, improving intercellular communication, and reinforcing the skin's protective barrier. Furthermore, it offers a protective effect against UVB-mediated cellular damage.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

SH-Oligopeptide-2, being a growth factor, is prone to destabilization in acidic environments, which can compromise its efficacy. For optimal performance, it is advisable to apply acidic skincare products such as AHAs or BHAs first, allowing a brief interval before layering products containing this ingredient.

Conflicts

  • Acidic environments (e.g., AHAs, BHAs)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

The Cosmetic Ingredient Review (CIR) Expert Panel has not yet assessed SH-Oligopeptide-2. While recognized as safe for cosmetic use by some regulatory bodies, caution is advised due to its growth factor-mimicking nature, as growth factors have been correlated with tumorigenesis or progression in specific contexts. Although serious side effects from topical application have not been reported, a small sensitivity test is recommended for individuals prone to dermatological issues.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

SH-Oligopeptide-2 is a valuable ingredient for promoting advanced skin regeneration and anti-aging due to its potent cellular signaling properties, although users should proceed with caution and perform a patch test given its growth factor activity and potential for individual sensitivities.

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