Science
Mechanism of Action
This single-chain recombinant human peptide is produced through controlled fermentation utilizing E. coli. It primarily operates by conditioning the skin and forming a protective barrier, thereby safeguarding the skin from various external aggressors. Scientific literature presents conflicting information regarding the human gene it is designed to mimic; some sources indicate identity with Interleukin-8 (CXCL8), a chemokine involved in immune responses and inflammation, while others suggest it replicates Interleukin-4 (CG-IL4), known for its roles in immune regulation, allergic responses, and wound healing.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
No specific safety assessments or maximum concentration guidelines from regulatory bodies such as CIR, SCCS, or FDA were publicly identified for SH-Oligopeptide-12. However, its inclusion within the CosIng database indicates its general acceptance for use in cosmetic products across the European Union.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While SH-Oligopeptide-12 presents a promising mechanism for skin conditioning and protection, there is currently insufficient public data on clinical efficacy and detailed safety assessments to provide a definitive recommendation.
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References
Sources