Science
Mechanism of Action
Upon topical application, SH-Oligopeptide-11 selectively binds to specific receptors on the surface of fibroblasts, initiating intracellular signaling cascades. This process critically stimulates the proliferation of both fibroblasts and keratinocytes, driving the production of structural proteins vital for reinforcing the skin's extracellular matrix. The result is improved skin texture, increased resilience, and enhanced synthesis of collagen and elastin. Furthermore, its notable antioxidant capacity helps neutralize free radicals, impede cellular aging, prevent programmed cell death, and bolster the skin's natural protective barriers, effectively diminishing the appearance of fine lines and deep wrinkles.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Clinical investigations, including randomized, multicenter, double-blind, and placebo-controlled trials, have robustly demonstrated that topical SH-Oligopeptide-11 significantly enhances skin health and repair. It notably accelerates wound healing, evidenced by increased wound tensile strength and heightened collagen deposition. Its efficacy extends to various clinical scenarios, including the improvement of pressure sores, and it consistently shortens recovery periods while stimulating essential cell proliferation for regeneration.
Transparency
Dusting Analysis
No data suggests this ingredient is commonly dusted.
The Formula
Formulation
Stability
Due to its substantial molecular size, SH-Oligopeptide-11 exhibits limited penetration of the stratum corneum; however, liposomal encapsulation significantly improves its delivery to deeper skin layers. Growth factors, including SH-Oligopeptide-11, are susceptible to destabilization in acidic environments, which can compromise their efficacy. It is advisable to apply acidic products and allow them to absorb for several minutes before layering formulations containing this growth factor.
Conflicts
- acidic environments
Safety
Safety Profile
SH-Oligopeptide-11 has not undergone a specific review by the Cosmetic Ingredient Review (CIR) Expert Panel. While broader reviews on 'Tissue-Derived Proteins and Peptides' exist, they do not specifically address this ingredient. No explicit regulatory information for SpecPed® sh-Oligopeptide-11 was identified in the available data.
Your Skin
Skin Compatibility
Our Assessment
Verdict
SH-Oligopeptide-11 is a valuable peptide for advanced skincare formulations, offering significant benefits in skin regeneration, wound healing, and anti-aging through its potent cellular signaling and extracellular matrix support.
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References
Sources