Science
Mechanism of Action
SH-OLIGOPEPTIDE-1, a synthetic recombinant analog of human Epidermal Growth Factor (EGF), functions as a potent cell-signaling peptide. It stimulates the proliferation of keratinocytes, endothelial cells, and fibroblasts, promoting skin self-regeneration, enhancing microcirculation, and boosting essential extracellular matrix components like collagen, elastin, and hyaluronic acid. This leads to improved skin barrier function, reduced inflammation, and scar minimization. SH-POLYPEPTIDE-7, a recombinant human peptide mirroring Somatotropin (human growth hormone), signals the skin to activate its natural repair mechanisms, supporting the regeneration of mature skin cells, strengthening its inherent structure, and contributing to a visible reduction in wrinkles by mimicking natural collagen fragment behavior. The specific mechanism of action for DIPEPTIDE-19 on the skin is currently not detailed in research.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Topical serum containing EGF demonstrated a 73% decrease in melasma in subjects after 8 weeks of twice-daily application, with no reported side effects.
- 02 An EGF cream reduced inflammatory acne lesions by 33.5% over six weeks, observed on half a face in a study of 20 subjects.
- 03 A serum with barley bioengineered epidermal growth factor showed statistically significant improvements in fine lines, wrinkles, skin texture, pore size, and dyschromatic conditions within one month, with sustained improvement over three months.
- 04 Topical application of sh-Oligopeptide-1 proved effective in accelerating wound healing for diabetic patients post-laser treatment and in managing Senile purpura.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
SH-OLIGOPEPTIDE-1 exhibits high sensitivity to pH, requiring formulations to maintain a pH between 5 and 8 for optimal stability. It is also susceptible to enzymatic degradation by microorganisms, necessitating stringent microbial control during processing. EGF peptides can be unstable at room temperature, with some studies indicating a significant loss of activity (only 5-10% remaining) if not stored under cold conditions. Due to its moderate size and polarity, skin penetration may require specialized delivery systems. Peptides generally can degrade through deamidation, oxidation, hydrolysis, and racemization, with aqueous solutions potentially experiencing reduced long-term stability.
Safety
Safety Profile
SH-OLIGOPEPTIDE-1 is generally considered safe for cosmetic applications and is approved under European Cosmetics Regulation. However, as a mitogenic growth factor, it stimulates cell proliferation. While not mutagenic, caution is advised for individuals with existing cancerous cells, a high number of moles, a history of significant UV exposure, or other skin cancer risk factors, as it could potentially promote the spread of pre-existing abnormal cells. It should also be avoided by those with psoriasis. Topical recombinant human EGF (hr-EGF) is not authorized as a medication outside of clinical trials, and sh-EGF (sh-oligopeptide-1) is authorized as a cosmetic in varying concentrations with unknown long-term risks. General peptides, including SH-POLYPEPTIDE-7 and DIPEPTIDE-19, have been broadly reviewed by CIR as safe for cosmetic use, though specific safety data for the latter two in this blend are not detailed.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This peptide blend offers significant rejuvenating and reparative benefits for diverse skin concerns, though careful consideration is advised for individuals with specific pre-existing skin conditions due to the mitogenic nature of SH-OLIGOPEPTIDE-1.
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