Science
Mechanism of Action
This ingredient is a single-chain synthetic fusion peptide, produced via fermentation in E. coli. It functions as a potent cellular signal molecule, primarily through its Epidermal Growth Factor (EGF) component, SH-Oligopeptide-1. It stimulates the proliferation of keratinocytes in the stratum corneum, endothelial cells, and fibroblasts, which are crucial for skin health. This activity promotes faster self-regeneration, enhances microcirculation, and boosts the secretion of various rejuvenating growth factors. The peptide significantly improves skin barrier function, helps to mitigate inflammatory responses, and supports the reduction of cutaneous scars. Furthermore, it aids in long-term moisturization and augments the production of essential extracellular matrix (ECM) components, including structural proteins like collagen and elastin, and glycosaminoglycans such as hyaluronic acid, contributing to skin's firmness, elasticity, and overall youthful appearance.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Studies on SH-Oligopeptide-1 indicate accelerated wound healing and a reduction in melasma. One investigation using a serum containing barley bioengineered EGF demonstrated statistically significant improvements in the appearance of fine lines, rhytids, skin texture, pore size, and dyschromatic conditions within one month, with sustained enhancement observed over three months.
- 02 A systematic review involving subjects who applied a topical EGF serum twice daily for 8 weeks reported that 73% experienced a reduction in melasma, with no observed side effects.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
For its SH-Oligopeptide-1 component, the ingredient maintains stable biological activity when stored, transported, and utilized at room temperature. It is recommended to incorporate it into formulations during the final step, ensuring the temperature remains below 45℃.
Safety
Safety Profile
Direct safety assessments by CIR, SCCS, or FDA for SH-OLIGOPEPTIDE-1 NONAPEPTIDE-29 are not readily available. The SH-Oligopeptide-1 component is authorized for general cosmetic use at various concentrations but with unknown long-term risks. It is considered mitogenic (stimulates cell proliferation) but not mutagenic (does not cause cancerous cell alterations), implying it will not induce cancer in individuals without existing malignancies.
Your Skin
Skin Compatibility
Our Assessment
Verdict
SH-OLIGOPEPTIDE-1 NONAPEPTIDE-29 is a valuable ingredient for promoting comprehensive skin rejuvenation, addressing concerns from signs of aging and pigmentation to barrier integrity and wound healing, making it highly compatible across all skin types.
Related
Similar Ingredients
Finding similar ingredients…