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Moumoujus

SH-NONAPEPTIDE-4.

Valuable / SKIN CONDITIONING

SH-NONAPEPTIDE-4 is a bio-mimetic peptide, an active fragment of the human Klotho protein, often referred to as an anti-aging factor. It targets multiple pathways to rejuvenate skin, enhance resilience, and protect against cellular damage.

Summary

skin conditioning anti-aging antioxidant skin repair elasticity booster pore refining

Science

Mechanism of Action

As a synthetic recombinant peptide, SH-NONAPEPTIDE-4 acts by activating various Fibroblast Growth Factors (FGF) linked to longevity and inhibiting Insulin Growth Factor (IGF) receptors associated with premature aging. It stimulates the endogenous production of critical antioxidant enzymes like Superoxide Dismutase (SOD) and Catalase, offering robust protection against reactive oxygen species and oxidative stress. Furthermore, it initiates DNA repair processes within skin cells, extending cellular lifespan and boosting cellular energy production for enhanced metabolism, function, and overall viability, thereby signaling the skin's natural repair mechanisms.

Research

Clinical Evidence

High confidence
Effective range 1–1%
Optimal

1%

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

SH-NONAPEPTIDE-4 is typically provided as a solution in phosphate buffered saline (PBS) alongside hyaluronic acid (HA) and standard preservatives. While no explicit optimal pH range is provided for this specific peptide, related nonapeptides suggest stability within a pH range of 5-7. Comprehensive stability testing across various temperatures and conditions is advisable for final formulations.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
1%
Sensitization risk Low

Safety evaluations have been conducted up to a 1% concentration without reported issues. While not yet reviewed by CIR, SCCS, or FDA, peptides generally demonstrate a favorable safety profile in cosmetic applications. INCI Beauty indicates 'No penalty' across all safety categories for SH-NONAPEPTIDE-4.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

SH-NONAPEPTIDE-4 is a valuable peptide for advanced skincare, demonstrating significant anti-aging efficacy by enhancing elasticity, reducing wrinkles, and improving cellular defense and repair mechanisms.

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