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Moumoujus

SH-NONAPEPTIDE-3.

Valuable / SKIN CONDITIONING

SH-Nonapeptide-3 is a biomimetic peptide engineered to meticulously replicate the benefits of retinoids, such as retinol and retinoic acid, without the associated irritation. It precisely targets cellular pathways to rejuvenate skin, enhance resilience, and promote a more uniform complexion.

Summary

Cell-communicating Skin-identical Anti-aging Collagen-boosting Exfoliating Barrier support Moisturizing Brightening Anti-inflammatory

Science

Mechanism of Action

This peptide, also known as Myristoyl Nonapeptide-3, functions by mimicking retinol's activity to stimulate cellular turnover and increase epidermal thickness, resulting in a smoother skin texture. It significantly boosts Type I collagen production, which is vital for maintaining skin structure and firmness. Furthermore, it enhances intercellular communication, fortifies the skin barrier, and improves moisture retention. Its inhibitory action on Matrix Metalloproteinase-1 (MMP-1) gene expression helps preserve existing collagen, while its capacity to hinder melanin gene expression, melanin synthesis, and tyrosinase activity contributes to reducing hyperpigmentation. Additionally, it may offer anti-inflammatory effects.

Research

Clinical Evidence

Medium confidence
Effective range 5–10%
Optimal

10%

Key findings

  1. 01 43% increase in collagen-1 production
  2. 02 Increased epidermal cellular layers/cell turnover

Transparency

Dusting Analysis

Not commonly dusted

Information regarding common dusting percentages or specific thresholds for this ingredient is not available in the provided research data.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The myristoyl group, a fatty acid attached to the nonapeptide-3, significantly enhances its skin penetration, suggesting excellent lipid compatibility. While specific optimal pH ranges are not publicly detailed for Myristoyl Nonapeptide-3, peptides typically exhibit optimal stability within a narrow pH range. It is versatile for incorporation into both base creams and water-based formulations.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Myristoyl Nonapeptide-3 is generally considered safe for topical application in cosmetic products. It is notable for its mild profile, being marketed as a retinol alternative that typically does not cause irritation or stinging. Side effects and adverse reactions are uncommon. There are no specific regulatory statuses or maximum concentration guidelines from CIR, SCCS, or FDA currently available.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

SH-Nonapeptide-3 is a valuable, irritation-free retinoid alternative that effectively boosts collagen, enhances cell turnover, and improves overall skin health across all skin types.

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