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Moumoujus

SH-NONAPEPTIDE-1.

Valuable / SKIN CONDITIONING

SH-NONAPEPTIDE-1 is a precision-engineered peptide designed to visibly reduce hyperpigmentation and enhance skin luminosity. It targets the core mechanisms of melanin production, leading to a more even and radiantly toned complexion.

Summary

Skin conditioning Skin lightening Anti-hyperpigmentation Melanin synthesis inhibition Luminosity enhancement

Science

Mechanism of Action

This peptide acts as a competitive antagonist, specifically binding to the MC1-R receptors found on melanocytes. By occupying these receptors, SH-NONAPEPTIDE-1 prevents the alpha-melanocyte-stimulating hormone (α-MSH) from triggering melanin synthesis. This mechanism effectively inhibits the key enzyme tyrosinase and downregulates factors such as TRP1, TRP2, and MITF, thereby reducing overall melanin production by approximately 33% without adverse effects on cellular health.

Research

Clinical Evidence

High confidence
Effective range 0.0001–0.0025%
Optimal

0.0005%

Transparency

Dusting Analysis

Not commonly dusted

No data available in current research to indicate 'dusting' concerns for SH-NONAPEPTIDE-1.

The Formula

Formulation

Solubility
Water
Optimal pH 4.5 – 7
0 7 14

Stability

For optimal stability and efficacy, SH-NONAPEPTIDE-1 is best formulated within a pH range of 4.5 to 7.0. This water-soluble peptide should be incorporated during the final phase of formulation, ensuring temperatures remain below 45°C, ideally not exceeding 40°C.

Conflicts

  • Formaldehyde-releasing preservatives

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

SH-NONAPEPTIDE-1 is generally considered safe for topical cosmetic application, demonstrating a low risk of irritation or adverse reactions across various skin types, including sensitive skin. It poses no known risks regarding cancer, developmental/reproductive toxicity, or allergies/immunotoxicity. The ingredient is listed in the Inventory of Existing Cosmetic Ingredients in China (IECIC) and is not restricted or prohibited by EU cosmetic regulations.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

SH-NONAPEPTIDE-1 is a valuable active ingredient for precision skincare, demonstrating strong efficacy in combating hyperpigmentation and boosting skin luminosity through a targeted melanin inhibition mechanism, with broad compatibility across all skin types.

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