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Moumoujus

SH-HEXAPEPTIDE-1.

Valuable / SKIN CONDITIONING

SH-HEXAPEPTIDE-1, also recognized as Acetyl Hexapeptide-1 or Melitane, is a sophisticated biomimetic peptide engineered to strategically regulate melanin production within the skin. It serves as a multi-functional active, offering targeted benefits for natural UV defense, photoaging prevention, and overall skin rejuvenation.

Summary

Skin conditioning Stimulates pigmentation Melanin production enhancer Natural UV protection DNA repair modulation Free radical damage protection Anti-redness/erythema Collagen synthesis booster Elastin synthesis booster Antioxidant Skin barrier strengthening Hydration Skin brightening Hyperpigmentation reduction Dark spot reduction Fine line and wrinkle reduction

Science

Mechanism of Action

Acting primarily as a melanin-regulating peptide, SH-HEXAPEPTIDE-1 stimulates the melanocortin-1 receptor (MC1-R) to enhance endogenous melanin synthesis. This mechanism provides a natural biological shield against UV-induced cellular damage and mitigates photoaging effects. Furthermore, it actively modulates DNA repair processes in both melanocytes and keratinocytes. Through MC1-R activation, it effectively limits the expression of key biochemical inflammation mediators, including IL-1, IL-8, PGE2, and Rantes, thereby reducing UV-induced erythema. Beyond its pigmentary role, SH-HEXAPEPTIDE-1 stimulates fibroblast activity to promote the synthesis of essential collagen and elastin, functions as an antioxidant to neutralize free radicals, and strengthens the epidermal barrier, leading to improved hydration, reduction of hyperpigmentation, and visible attenuation of fine lines and wrinkles.

Research

Clinical Evidence

Medium confidence
Effective range 0.02–0.02%
Optimal

0.02%

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.02%

The clinically proven effective concentration of SH-HEXAPEPTIDE-1 is 0.02%. Formulations containing this ingredient below this specific threshold are unlikely to yield the observed benefits, indicating it is not an ingredient commonly used for 'dusting' at ineffective concentrations.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 6.5
0 7 14

Stability

For optimal stability, SH-HEXAPEPTIDE-1 should be stored at -20°C to -15°C for up to 24 months from the manufacturing date, protected from light and kept air-proofed. For long-term refrigeration, 5°C with light avoidance is recommended. It is critical to avoid exposure to temperatures exceeding 40°C during the mixing or formulation process.

Synergies

  • Hyaluronic acid
  • Vitamin C

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) has not conducted a specific safety assessment for SH-HEXAPEPTIDE-1 (Acetyl Hexapeptide-1). However, general dermatological evaluations indicate a low risk of irritation and sensitivity, categorizing it as hypoallergenic and suitable for most skin types, including sensitive skin. Adherence to low concentrations and initial patch testing is advised.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

SH-HEXAPEPTIDE-1 is a valuable multi-functional peptide offering significant benefits in anti-aging, UV protection, pigmentation regulation, and skin barrier support, with demonstrated efficacy at a precise concentration of 0.02% across various skin types.

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