Science
Mechanism of Action
This advanced synthetic peptide operates through multifaceted mechanisms to combat skin aging. Structurally composed of Gly-Tyr-Tyr-Glu-Leu-Asn-Asp-NH2, it stimulates collagen production, which is essential for maintaining dermal structure and resilience. It actively protects against cellular aging by enhancing the expression and synthesis of Telomeric repeat-binding factor 1 (TRF1) protein, thereby safeguarding telomeres. As a potent antioxidant, SH-HEPTAPEPTIDE-6 SP boosts catalase production to efficiently neutralize reactive oxygen species (ROS) such as hydrogen peroxide, protecting skin cells from oxidative stress. Furthermore, it exhibits anti-inflammatory properties by reducing Interleukin-8 (IL-8) levels and modulating relevant gene expression. The peptide also promotes skin cell growth and proliferation, and has demonstrated the ability to reduce fat cell accumulation and count.
Research
Clinical Evidence
Medium confidence0.1%
Key findings
- 01 Demonstrated effectiveness as an anti-aging, anti-wrinkle, fat-reducing, firming, and skin repair ingredient.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
As a peptide, it is generally advised to avoid extreme pH levels, high temperatures, and specific enzymatic systems in formulations to maintain its structural integrity and efficacy. Specific optimal pH ranges and detailed stability data are not publicly available.
Safety
Safety Profile
While not formally reviewed by the CIR Expert Panel, SH-HEPTAPEPTIDE-6 SP is widely considered safe for cosmetic applications by manufacturers. It is reported to be free from heavy metals and is classified as 'Irritant Free', indicating a low risk of skin and eye irritation.
Your Skin
Skin Compatibility
Our Assessment
Verdict
SH-HEPTAPEPTIDE-6 SP is a valuable, multifunctional peptide offering significant anti-aging, firming, and protective benefits, suitable for a wide range of precision skincare applications.
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