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SH-HEPTAPEPTIDE-4 SP TRIFLUOROACETATE.

Valuable / HUMECTANT, SKIN CONDITIONING

SH-HEPTAPEPTIDE-4 SP TRIFLUOROACETATE is a precision peptide engineered to optimize the skin's microbiota, bolster natural defenses, and enhance barrier integrity. It works to soothe sensitive skin, diminish irritation, and boost hydration for a healthier, more radiant complexion.

Summary

skin-identical ingredient moisturizer/humectant prebiotic soothing skin barrier support microbiome balancing natural defense booster hydration enhancer

Science

Mechanism of Action

This peptide, also known as Acetyl Heptapeptide-4 or Fensebiome™, functions primarily as a prebiotic, rebalancing the skin's microbiota. It selectively promotes the proliferation of beneficial bacteria and strengthens the skin's intrinsic immune response against harmful microbes. By enhancing dermal cell cohesion, it fortifies the physical barrier, leading to improved skin integrity, reduced sensitivity, and greater resilience against environmental stressors.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

0.005%

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

For optimal stability, Acetyl Heptapeptide-4 should be stored at -20°C to -15°C in a freezer, protected from light, and kept air-proofed. The container must be tightly closed and stored in a cool, dry place away from direct sunlight, ensuring a shelf life of up to 24 months from the date of manufacture.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While specific CIR or SCCS assessments for this peptide are currently unavailable, Acetyl Heptapeptide-4 (Fensebiome™) is generally described as a safe and effective ingredient for topical applications. The trifluoroacetate counterion, a common byproduct of peptide purification, is a fluorinated compound. Concerns regarding PFAS have been raised by the EWG for different trifluoroacetate salts, though scientific opinions on their safety can vary. Residual trifluoroacetate levels in standard in vitro assays typically do not cause interference.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

SH-HEPTAPEPTIDE-4 SP TRIFLUOROACETATE is a valuable peptide that significantly strengthens the skin barrier and immune response by promoting a healthy microbiome and enhancing hydration, making it ideal for sensitive and fragile skin types.

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