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SH-HEPTAPEPTIDE-2.

Valuable / SKIN CONDITIONING

SH-HEPTAPEPTIDE-2 is a precision-engineered peptide targeting both hyperpigmentation and signs of aging. It visibly brightens skin, reduces dark spots, and evens out skin tone by influencing melanin production, while simultaneously promoting collagen synthesis for improved texture and reduced fine lines.

Skin Conditioning Skin Brightening Anti-Aging Reduces Hyperpigmentation Evens Skin Tone Collagen Boosting Improves Skin Texture

Science

This peptide primarily functions as a skin brightener by competitively binding to alpha-MSH receptors on melanocytes, reducing the signaling cascade for melanin synthesis. Its structural similarity to alpha-MSH allows it to partially block these receptors, subsequently decreasing melanin production and transfer to keratinocytes. Additionally, SH-HEPTAPEPTIDE-2 is reported to stimulate endogenous collagen production, thereby enhancing skin firmness, refining texture, and mitigating the appearance of fine lines and wrinkles.


Research

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Clinical observations suggest SH-HEPTAPEPTIDE-2 (referenced as Hexapeptide-2) effectively brightens skin, combats dark spots and hyperpigmentation, and evens skin tone.
  2. 02 Studies indicate its use in anti-aging products promotes collagen production, improving skin texture and reducing the appearance of fine lines and wrinkles.

Transparency

Not commonly dusted

The Formula

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

A specific optimal pH range for SH-HEPTAPEPTIDE-2 stability was not identified, though peptide stability generally exhibits pH sensitivity.


Safety

CIR Status
Insufficient data
Sensitization risk Low

SH-HEPTAPEPTIDE-2 is generally considered safe for cosmetic use with no known associated side effects. However, a dedicated safety assessment from CIR or SCCS specifically for SH-HEPTAPEPTIDE-2 (or SH-Hexapeptide-2, as referenced in the provided research data) as a standalone ingredient has not been found. Reviews for other related hexapeptides suggest safety at low concentrations.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Valuable

SH-HEPTAPEPTIDE-2 (based on data for SH-Hexapeptide-2) presents as a valuable multi-functional ingredient for combating hyperpigmentation and signs of aging across all skin types, though specific optimal concentrations and a dedicated safety assessment for this precise peptide remain unestablished.


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