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SH-HEPTAPEPTIDE-10 SP.

Insufficient Data / SKIN CONDITIONING - MISCELLANEOUS

SH-HEPTAPEPTIDE-10 SP is a synthetic human peptide meticulously engineered to mimic a specific portion of the Angiopoietin-1 protein. It functions as a sophisticated skin conditioning agent, signaling the body's natural repair pathways. This action is designed to promote cellular regeneration and strengthen the skin's structural integrity, contributing to anti-aging benefits.

skin conditioning antioxidant support skin regeneration structural strengthening UV damage protection wrinkle reduction

Science

As a synthetic human peptide, SH-HEPTAPEPTIDE-10 SP precisely replicates a segment of the crucial Angiopoietin-1 protein. Its primary mode of action in skincare is to function as a sophisticated cellular messenger, stimulating the skin's inherent repair and regeneration mechanisms. This signaling capacity is hypothesized to foster renewal in mature skin, fortify its structural integrity, and contribute to the visible reduction of fine lines and wrinkles. Furthermore, related peptides, such as Acetyl sh-Heptapeptide-1, are known to activate the Nrf2 pathway by interacting with Keap1. This activation upregulates the synthesis of vital cell-protective enzymes, significantly boosting the skin's intrinsic antioxidant defenses, shielding DNA from oxidative damage, and effectively neutralizing free radicals generated by UV exposure and environmental stressors.


Research

Low confidence
Effective range 0.014–0.014%
Optimal

0.014%


Transparency

Not commonly dusted

The Formula

Solubility
Unknown
Optimal pH N/A
0 7 14

Safety

CIR Status
Not reviewed
Sensitization risk Unknown

The European Commission's CosIng database lists SH-HEPTAPEPTIDE-10 SP as a skin conditioning agent without specific SCCS opinions. Comprehensive safety assessments for peptides are highly specific to their molecular structure and concentration. For instance, the Cosmetic Ingredient Review (CIR) found Acetyl Hexapeptide-8 Amide safe up to 0.005%, but noted insufficient data for higher concentrations. Similarly, sh-oligopeptide-1 is authorized for cosmetic use in various concentrations, but with long-term risks remaining undefined.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Insufficient Data

While SH-HEPTAPEPTIDE-10 SP exhibits a compelling mechanism for skin protection and regeneration, comprehensive direct clinical efficacy data specifically for this peptide is currently limited, relying instead on studies of related compounds.


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