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Moumoujus

SH-HEPTAPEPTIDE-1.

Valuable / SKIN CONDITIONING

SH-HEPTAPEPTIDE-1 is a sophisticated biomimetic peptide engineered to enhance the skin's intrinsic defense mechanisms. It actively shields against environmental aggressors like UV radiation and oxidative stress, safeguarding cellular DNA and immune function. By boosting antioxidant capacity and neutralizing free radicals, this peptide effectively counters both environmental and chronological signs of skin aging.

Summary

Antioxidant Anti-aging Skin conditioning UV protection (indirect) DNA protection Immune protection

Science

Mechanism of Action

SH-HEPTAPEPTIDE-1, specifically Acetyl sh-Heptapeptide-1 (PerfectionPeptide P7), functions as a synthetic recombinant peptide mimicking a critical sequence of the Nrf2 protein. Nrf2 is a master transcription factor that upregulates the synthesis of cell-protective enzymes, which neutralize free radicals, detoxify cellular components, and replenish endogenous antioxidants such as glutathione. This peptide specifically binds to the Keap1 protein, which typically suppresses Nrf2 activity. By disrupting the Nrf2/Keap1 complex, SH-HEPTAPEPTIDE-1 effectively liberates and activates Nrf2, thereby inducing the production of the skin's inherent defensive and reparative enzyme systems.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

As a polypeptide, SH-HEPTAPEPTIDE-1 requires storage under controlled temperature and light exposure conditions, typically as specified in its Certificate of Analysis (CoA), to maintain optimal stability.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Information regarding the CIR, SCCS, or FDA status specifically for SH-HEPTAPEPTIDE-1 was not found. While some sources consider it bioequivalent to sh-oligopeptide-1 (sh-EGF), which is authorized for cosmetic use, the long-term risks and scientific basis of some clinical studies for sh-EGF have been questioned.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

SH-HEPTAPEPTIDE-1 is a valuable peptide for advanced skincare formulations, effectively boosting the skin's antioxidant defenses and protecting against environmental damage and premature aging by activating the Nrf2 pathway.

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