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Moumoujus

SH-DECAPEPTIDE-3.

Valuable / BLEACHING, SKIN PROTECTING

SH-DECAPEPTIDE-3, also identified as Acetyl Decapeptide-3 or CG-Rejuline, is a synthetic biomimetic peptide designed to support advanced skin regeneration. It mimics basic Fibroblast Growth Factor (bFGF), a crucial protein for skin development and healing, thereby stimulating essential protein production and enhancing skin's structural integrity for a youthful appearance.

Summary

Anti-aging Skin regeneration Wound healing Collagen stimulation Elastin stimulation Skin firmness enhancement Skin elasticity improvement Wrinkle reduction New cell generation Cell protection

Science

Mechanism of Action

This synthetic peptide operates as a biomimetic of basic Fibroblast Growth Factor (bFGF), a fundamental protein involved in skin development, wound healing, and cellular regeneration. It actively stimulates the synthesis of crucial dermal proteins including collagen, elastin, fibronectin, and laminin. This multi-faceted action leads to improved skin texture, increased firmness, and enhanced elasticity, while concurrently mitigating the appearance of fine lines and wrinkles. Furthermore, SH-DECAPEPTIDE-3 promotes the generation of new skin cells, aids in normal skin growth and repair, and offers protection against cellular apoptosis.

Research

Clinical Evidence

Medium confidence
Effective range 0.002–0.005%
Optimal

N/A

Key findings

  1. 01 Suppliers recommend a use level between 0.002% and 0.005% for Acetyl Decapeptide-3 to achieve anti-aging and skin repair benefits.
  2. 02 Clinical tests have shown Acetyl Decapeptide-3 (CG-Rejuline) to exhibit superior stability and prolonged action compared to naive bFGF, leading to a reduction in fine lines and wrinkles, improved skin elasticity, and enhanced firmness and suppleness.
  3. 03 In a real-world study, a 0.1% concentration of Decapeptide was found to be more effective than 0.1% betamethasone valerate in the treatment of vitiligo, suggesting strong regenerative capabilities.

Transparency

Dusting Analysis

Not commonly dusted

No data available in the provided research to suggest SH-DECAPEPTIDE-3 is commonly dusted or to establish a dusting threshold.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

SH-DECAPEPTIDE-3, as a synthetic peptide, is engineered for enhanced stability and prolonged biological activity relative to native proteins. To ensure optimal stability within formulations, it should be incorporated at temperatures below 40 °C. Peptide stability is broadly influenced by factors such as pH, electrical charge, molecular weight, specific concentration, and the composition of background electrolytes.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Specific safety assessments for SH-DECAPEPTIDE-3 or its synonym, Acetyl Decapeptide-3, by regulatory bodies like CIR, SCCS, or FDA were not explicitly identified. While general CIR reports on 'Tissue-Derived Proteins and Peptides' typically conclude safety under current cosmetic uses, these specific decapeptides are not individually detailed or evaluated within those reports.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

SH-DECAPEPTIDE-3 is a valuable biomimetic peptide, actively supporting skin regeneration and the synthesis of crucial structural proteins, making it a significant asset for anti-aging and skin repair formulations.

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