Science
Mechanism of Action
This unique single-chain synthetic fusion peptide operates primarily through SH-Polypeptide-11, also known as Acidic Fibroblast Growth Factor (aFGF). Upon topical application, SH-Polypeptide-11 specifically binds to receptors on dermal cells, particularly fibroblasts, initiating a cascade of cellular events. This stimulates significant fibroblast proliferation and growth, leading to increased production of essential structural proteins such as collagen and elastin, which contributes to an uplifted and more resilient skin appearance. It also functions as a potent antioxidant, neutralizing free radicals, thereby inhibiting skin cell aging and reinforcing the skin's natural defenses against environmental stressors to visibly reduce fine lines and deep wrinkles. This process of cell proliferation and tissue regeneration reinforces the skin's extracellular matrix. Additionally, this ingredient is noted to enhance primary hair cell proliferation and improve vascularization and blood circulation. While the precise mechanism of SH-Decapeptide-1 within this fusion peptide is not fully detailed, decapeptides typically serve as crucial signaling molecules involved in various cellular processes.
Research
Clinical Evidence
High confidence0.1%
Key findings
- 01 Topical application of rh-aFGF (SH-Polypeptide-11) has been demonstrated in randomized, multicenter, double-blind, and placebo-controlled clinical trials to accelerate wound healing and shorten recovery periods. In vitro studies further confirmed its strong stimulation of fibroblast and keratinocyte proliferation, noting that an appropriate carrier system, such as lipid spheres, is crucial for effective skin penetration.
- 02 A 0.1% solution of a bFGF-related decapeptide has shown effectiveness in stimulating melanocyte growth and migration, supporting re-pigmentation in patients with vitiligo in a real-world study, suggesting a potential role for the decapeptide component in skin tone uniformity.
Transparency
Dusting Analysis
Specific data regarding typical formulation percentages or 'dusting' prevalence for SH-DECAPEPTIDE-1 SH-POLYPEPTIDE-11 is not available in the provided research, making it difficult to establish a dusting threshold.
The Formula
Formulation
Stability
SH-Polypeptide-11 (aFGF) has a large molecular size, which hinders its penetration of the stratum corneum independently. However, formulation within carrier systems like liposomes significantly enhances its ability to reach deeper skin layers. Peptides generally exhibit optimal solubility in water or aqueous buffers, especially those with more than 25% charged residues.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has assessed a broad category of proteins and peptides, including those derived from skin and connective tissue, concluding they are safe under current practices of use and concentration. While 'SH-DECAPEPTIDE-1 SH-POLYPEPTIDE-11' itself is not explicitly listed, its constituent SH-Polypeptide-11 is widely considered safe, effective, and well-tolerated by the skin. SkinSAFE data for SH-Polypeptide-11 indicates it is free from common irritants, allergens, and potentially harmful chemicals, receiving 'Teen SAFE', 'Lip SAFE', 'Baby SAFE', and 'Eyelid SAFE' ratings.
Your Skin
Skin Compatibility
Our Assessment
Verdict
SH-DECAPEPTIDE-1 SH-POLYPEPTIDE-11 is a valuable multi-functional peptide supported by strong clinical evidence for its regenerative, anti-aging, and wound-healing capabilities, along with a high safety profile and broad skin compatibility.
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