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Moumoujus

SH-DECAPEPTIDE-1 SH-OLIGOPEPTIDE-2.

Avoid / SKIN CONDITIONING

This peptide complex combines SH-DECAPEPTIDE-1, implicated in supporting skin re-pigmentation, with SH-OLIGOPEPTIDE-2 (Insulin-like Growth Factor 1), a potent growth factor. It is designed to stimulate cellular regeneration, facilitate wound healing, and enhance the production of key extracellular matrix components to combat visible signs of aging.

Summary

Skin Conditioning Anti-aging Cell Regeneration Wound Healing Collagen Production Elastin Production Hyaluronic Acid Production Re-pigmentation

Science

Mechanism of Action

SH-DECAPEPTIDE-1 is understood to interact with basic fibroblast growth factor (bFGF)-related peptides, which are involved in promoting the skin's natural re-pigmentation processes. SH-OLIGOPEPTIDE-2, also known as Insulin-like Growth Factor 1 (IGF-1), acts as a significant growth factor that drives cell regeneration and aids in wound healing. It stimulates skin cell proliferation, potentially synergizing with Epidermal Growth Factor (SH-Oligopeptide-1). This peptide activates cellular signaling within the AKT pathway to mitigate aging effects, boost the biosynthesis of hyaluronic acid and other vital extracellular matrix components, and promote the production of collagen and elastin. These actions collectively aim to diminish the appearance of fine lines, deep wrinkles, and reduce skin blotchiness.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No specific data suggests this ingredient is commonly included at sub-efficacious 'dusting' levels, nor are specific efficacy thresholds defined in the provided research.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

Growth factor peptides are generally sensitive to environmental factors such as light, heat, and oxidation. To maintain their chemical integrity and biological activity within formulations, protective measures like encapsulation are frequently necessary.

Synergies

  • SH-Oligopeptide-1 (Epidermal Growth Factor)

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk Unknown

Information specifically on the combined ingredient SH-DECAPEPTIDE-1 SH-OLIGOPEPTIDE-2 is limited. For related growth factor peptides, preclinical bioactivity for cosmetic applications has not been definitively proven, and potential long-term risks associated with generalized cosmetic use are unknown. Critically, growth factors, including Insulin-like Growth Factor 1 (SH-OLIGOPEPTIDE-2), have been correlated with tumorigenesis or progression, with recombinant IGF-1 specifically linked to Melanoma progression. This correlation necessitates extreme caution regarding its use, especially in skincare products.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Due to the serious correlation between Insulin-like Growth Factor 1 (SH-OLIGOPEPTIDE-2) and tumorigenesis, including melanoma progression, this ingredient carries significant safety risks that outweigh its purported benefits for precision skincare applications, thus it should be avoided.

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